Featured Research

from universities, journals, and other organizations

Discovery On Cell Division Aids Search For Anti-Cancer Drugs

Date:
March 27, 2000
Source:
University Of Glasgow
Summary:
Researchers at the University of Glasgow have discovered a new mechanism which controls the ability of cells to divide and multiply. The breakthrough has important implications for the development of drugs to combat cancer, which occurs when cell division goes out of control.

Researchers at the University of Glasgow have discovered a new mechanism which controls the ability of cells to divide and multiply. The breakthrough has important implications for the development of drugs to combat cancer, which occurs when cell division goes out of control.

Dr Lorna Morris and Dr Elizabeth Allen, working under the direction of Professor Nick La Thangue in the Institute of Biomedical & Life Sciences,University of Glasgow, have been studying a cell protein called E2F which controls cell growth and division.

Their research identifies a complex of proteins* which activate E2F, thus initiating cell division. But if these control proteins are faulty and E2F is over-activated, excessive cell division takes place. This can lead to cancer.

"This is an important breakthrough" says Professor La Thangue, "because by understanding the natural mechanisms which regulate E2F, we can understand what is going wrong. This provides us with the opportunity to develop small molecule drugs which can arrest E2F activity and prevent tumour cell proliferation."

This research contributes to a larger programme of work identifying targets for drug development being carried out by Prolifix Ltd, the UK-based cell cycle company. Professor La Thangue is chief scientific officer of the company, which has a unique understanding of how the cell cycle is controlled in nature.

Failures or aberrations in the control of the cell cycle lie behind cancer and a number of other diseases. The race is on to develop custom-made drugs to compensate for the failures in the natural control mechanisms. Says Professor La Thangue: "The research teams working on this at the University of Glasgow are making a substantial contribution to our understanding of this vital area. The more information we have of how the process of cell cycle control works, the better placed we are to devise ways of intervening effectively when it goes wrong."

* The complex of proteins identified by the researchers are cyclin E-Cdk2 kinase and group known as p300/CBP.


Story Source:

The above story is based on materials provided by University Of Glasgow. Note: Materials may be edited for content and length.


Cite This Page:

University Of Glasgow. "Discovery On Cell Division Aids Search For Anti-Cancer Drugs." ScienceDaily. ScienceDaily, 27 March 2000. <www.sciencedaily.com/releases/2000/03/000327084518.htm>.
University Of Glasgow. (2000, March 27). Discovery On Cell Division Aids Search For Anti-Cancer Drugs. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2000/03/000327084518.htm
University Of Glasgow. "Discovery On Cell Division Aids Search For Anti-Cancer Drugs." ScienceDaily. www.sciencedaily.com/releases/2000/03/000327084518.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins