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Early Prostate Cancer Detected In Molecular-Based Urine Test

Date:
April 20, 2000
Source:
Fox Chase Cancer Center
Summary:
Researchers at Fox Chase Cancer Center in Philadelphia, Pa. say prostate cancer can be detected in urine. The findings of a new study were presented today (April 2) at the American Association for Cancer Research in San Francisco.
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PHILADELPHIA (April 2, 2000) -- Researchers at Fox Chase Cancer Center in Philadelphia, Pa. say prostate cancer can be detected in urine. The findings of a new study were presented today at the American Association for Cancer Research in San Francisco.

"Prostate cancer is curable if detected early and it is likely that there are cancer cells in body fluids years before cancer is clinically detectable. If we can find those cells, we can cure more prostate cancers," explained Paul Cairns, Ph.D. of Fox Chase Cancer Center.

Cairns and his colleagues at Johns Hopkins University (JHU), chose to screen urine DNA for a common, early genetic change unique to cancer cells called hypermethylation at the glutathione-S-transferase (GSTP1) gene using a sensitive PCR (polymerase chain reaction) test. GSTP1 hypermethylation is found in more than 90% of prostate cancers but not in normal tissues or in BPH, making it a very specific marker for the disease.

Investigators collected tumor samples and urine specimens from 28 men known to have surgically curable prostate cancers. Specimens were coded to prevent investigator bias. Of the 28 tumor DNAs, 22 showed GSTP1 methylation and could be compared with urine samples. For 6 of these 22 tumors, the corresponding urine DNA was also positive for GSTP1 methylation, confirming the potential of this test to detect curable prostate cancers. There were no false-positive results.

"We are optimistic that future research and continuing improvements in molecular technology will increase the detection rate. Screening tests should be reliable, inexpensive, and noninvasive. Urine tests meet these standards," said Dr. Cairns. "Furthermore, we already know from Dr. Sidransky's (JHU) work that a urine test can detect almost all bladder cancers and many kidney cancers. In the future, it's quite possible that the same urine specimen could be used to test for prostate, bladder and kidney cancer."

Fox Chase Cancer Center, one of the nation's first comprehensive cancer centers designated by the National Cancer Institute in 1974, conducts basic and clinical research; programs of prevention, detection and treatment of cancer; and community outreach. For more information about Fox Chase activities, visit the center's web site at: http://www.fccc.edu .


Story Source:

The above post is reprinted from materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


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Fox Chase Cancer Center. "Early Prostate Cancer Detected In Molecular-Based Urine Test." ScienceDaily. ScienceDaily, 20 April 2000. <www.sciencedaily.com/releases/2000/04/000406090853.htm>.
Fox Chase Cancer Center. (2000, April 20). Early Prostate Cancer Detected In Molecular-Based Urine Test. ScienceDaily. Retrieved August 30, 2015 from www.sciencedaily.com/releases/2000/04/000406090853.htm
Fox Chase Cancer Center. "Early Prostate Cancer Detected In Molecular-Based Urine Test." ScienceDaily. www.sciencedaily.com/releases/2000/04/000406090853.htm (accessed August 30, 2015).

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