Featured Research

from universities, journals, and other organizations

Early Prostate Cancer Detected In Molecular-Based Urine Test

Date:
April 20, 2000
Source:
Fox Chase Cancer Center
Summary:
Researchers at Fox Chase Cancer Center in Philadelphia, Pa. say prostate cancer can be detected in urine. The findings of a new study were presented today (April 2) at the American Association for Cancer Research in San Francisco.

PHILADELPHIA (April 2, 2000) -- Researchers at Fox Chase Cancer Center in Philadelphia, Pa. say prostate cancer can be detected in urine. The findings of a new study were presented today at the American Association for Cancer Research in San Francisco.

Related Articles


"Prostate cancer is curable if detected early and it is likely that there are cancer cells in body fluids years before cancer is clinically detectable. If we can find those cells, we can cure more prostate cancers," explained Paul Cairns, Ph.D. of Fox Chase Cancer Center.

Cairns and his colleagues at Johns Hopkins University (JHU), chose to screen urine DNA for a common, early genetic change unique to cancer cells called hypermethylation at the glutathione-S-transferase (GSTP1) gene using a sensitive PCR (polymerase chain reaction) test. GSTP1 hypermethylation is found in more than 90% of prostate cancers but not in normal tissues or in BPH, making it a very specific marker for the disease.

Investigators collected tumor samples and urine specimens from 28 men known to have surgically curable prostate cancers. Specimens were coded to prevent investigator bias. Of the 28 tumor DNAs, 22 showed GSTP1 methylation and could be compared with urine samples. For 6 of these 22 tumors, the corresponding urine DNA was also positive for GSTP1 methylation, confirming the potential of this test to detect curable prostate cancers. There were no false-positive results.

"We are optimistic that future research and continuing improvements in molecular technology will increase the detection rate. Screening tests should be reliable, inexpensive, and noninvasive. Urine tests meet these standards," said Dr. Cairns. "Furthermore, we already know from Dr. Sidransky's (JHU) work that a urine test can detect almost all bladder cancers and many kidney cancers. In the future, it's quite possible that the same urine specimen could be used to test for prostate, bladder and kidney cancer."

Fox Chase Cancer Center, one of the nation's first comprehensive cancer centers designated by the National Cancer Institute in 1974, conducts basic and clinical research; programs of prevention, detection and treatment of cancer; and community outreach. For more information about Fox Chase activities, visit the center's web site at: http://www.fccc.edu .


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Early Prostate Cancer Detected In Molecular-Based Urine Test." ScienceDaily. ScienceDaily, 20 April 2000. <www.sciencedaily.com/releases/2000/04/000406090853.htm>.
Fox Chase Cancer Center. (2000, April 20). Early Prostate Cancer Detected In Molecular-Based Urine Test. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2000/04/000406090853.htm
Fox Chase Cancer Center. "Early Prostate Cancer Detected In Molecular-Based Urine Test." ScienceDaily. www.sciencedaily.com/releases/2000/04/000406090853.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins