Featured Research

from universities, journals, and other organizations

Early Prostate Cancer Detected In Molecular-Based Urine Test

Date:
April 20, 2000
Source:
Fox Chase Cancer Center
Summary:
Researchers at Fox Chase Cancer Center in Philadelphia, Pa. say prostate cancer can be detected in urine. The findings of a new study were presented today (April 2) at the American Association for Cancer Research in San Francisco.

PHILADELPHIA (April 2, 2000) -- Researchers at Fox Chase Cancer Center in Philadelphia, Pa. say prostate cancer can be detected in urine. The findings of a new study were presented today at the American Association for Cancer Research in San Francisco.

Related Articles


"Prostate cancer is curable if detected early and it is likely that there are cancer cells in body fluids years before cancer is clinically detectable. If we can find those cells, we can cure more prostate cancers," explained Paul Cairns, Ph.D. of Fox Chase Cancer Center.

Cairns and his colleagues at Johns Hopkins University (JHU), chose to screen urine DNA for a common, early genetic change unique to cancer cells called hypermethylation at the glutathione-S-transferase (GSTP1) gene using a sensitive PCR (polymerase chain reaction) test. GSTP1 hypermethylation is found in more than 90% of prostate cancers but not in normal tissues or in BPH, making it a very specific marker for the disease.

Investigators collected tumor samples and urine specimens from 28 men known to have surgically curable prostate cancers. Specimens were coded to prevent investigator bias. Of the 28 tumor DNAs, 22 showed GSTP1 methylation and could be compared with urine samples. For 6 of these 22 tumors, the corresponding urine DNA was also positive for GSTP1 methylation, confirming the potential of this test to detect curable prostate cancers. There were no false-positive results.

"We are optimistic that future research and continuing improvements in molecular technology will increase the detection rate. Screening tests should be reliable, inexpensive, and noninvasive. Urine tests meet these standards," said Dr. Cairns. "Furthermore, we already know from Dr. Sidransky's (JHU) work that a urine test can detect almost all bladder cancers and many kidney cancers. In the future, it's quite possible that the same urine specimen could be used to test for prostate, bladder and kidney cancer."

Fox Chase Cancer Center, one of the nation's first comprehensive cancer centers designated by the National Cancer Institute in 1974, conducts basic and clinical research; programs of prevention, detection and treatment of cancer; and community outreach. For more information about Fox Chase activities, visit the center's web site at: http://www.fccc.edu .


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Early Prostate Cancer Detected In Molecular-Based Urine Test." ScienceDaily. ScienceDaily, 20 April 2000. <www.sciencedaily.com/releases/2000/04/000406090853.htm>.
Fox Chase Cancer Center. (2000, April 20). Early Prostate Cancer Detected In Molecular-Based Urine Test. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2000/04/000406090853.htm
Fox Chase Cancer Center. "Early Prostate Cancer Detected In Molecular-Based Urine Test." ScienceDaily. www.sciencedaily.com/releases/2000/04/000406090853.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Shoveling Snow: How to Prevent Back Injuries

Shoveling Snow: How to Prevent Back Injuries

Washington Post (Jan. 26, 2015) What&apos;s the proper technique for shoveling snow? A physical therapist offers specific tips for protecting your back while you dig out this winter. Video provided by Washington Post
Powered by NewsLook.com
Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins