Featured Research

from universities, journals, and other organizations

Transplanted Human Stem Cells Develop into Broad Range of Tissues, Persist over a Year in Research at The Children's Hospital of Philadelphia

Date:
November 1, 2000
Source:
The Children's Hospital of Philadelphia
Summary:
Adult human mesenchymal stem cells, taken from bone marrow, have been induced to develop into a wide range of normal tissue after transplantation into fetal sheep. The transplanted cells have persisted over a year without immune system rejection, in research with potential implications for tissue engineering in diseases such as muscular dystrophy.

Philadelphia, Pa. — Adult human stem cells taken from bone marrow have been induced to develop into a wide range of normal tissues, including bone, cartilage, fat, tendon and muscle, when transplanted into fetal sheep. The transplanted human cells have persisted in various sheep tissues for over one year without rejection by the sheep’s immune system. The study offers promise that in the future these cells may be useful for tissue repair or regeneration and for treatment of degenerative diseases such as muscular dystrophy.

"Although a great deal of work remains to be done, these results suggest great potential for the use of these cells in repair of damaged or degenerating tissues, or for generation of new tissues, a process called tissue engineering," said Alan W. Flake, M.D., director of The Children’s Institute for Surgical Science at The Children’s Hospital of Philadelphia, who led the study reported in the November issue of Nature Medicine. "One possible future application might be the transplantation of normal stem cells into a fetus diagnosed with muscular dystrophy. "These cells could then act as a normal stem cell ‘reservoir’ and replace the abnormal muscle with normal muscle as it degenerates over time."

Stem cells are immature cells that develop into specialized cells throughout the body, and those taken from embryos have the broadest potential for giving rise to all the body’s tissues. However, recent studies have shown that cells with broad stem cell potential can be found in various adult tissues as well, including the bone marrow and nervous system.

In the study at Children’s Hospital, researchers harvested mesenchymal stem cells (MSCs) from adult bone marrow. "The transplanted cells developed in a site-specific fashion," said Dr. Flake. "They migrated to different parts of the sheep’s body and differentiated into types of tissue present at each site."

Because the transplanted cells carried human DNA, it was possible to identify them in different tissue. They became cells in skeletal muscle, heart muscle, bone, cartilage, the thymus gland and stroma, which is supporting structure for bone marrow. Furthermore, transplanted human MSCs were found at the site of clipped tails in the sheep, suggesting that those cells were involved in wound healing.

MSC transplants may have a future role in enhancing wound healing after an injury or surgery. Additionally, said Dr. Flake, because MSCs also develop into supporting cells in bone marrow, they might provide a more favorable environment for the transplanted cells used in bone marrow transplants for leukemias and other blood-based diseases. MSCs might also be used in gene therapy, acting as vehicles to deliver beneficial genes to targeted tissues.

Although many institutions are currently investigating various types of stem cells, this is the first study examining transplantation of human MSCs in the fetal sheep model. In this current study, human MSCs were transplanted into fetal sheep early in gestation, at either 65 days or 85 days, before and after the brief window of time when their immune systems mature and become active.

One surprise of the study, according to Dr. Flake, is the persistence of these transplanted cells even in animals that were capable of rejecting foreign cells at the time of transplantation. "This suggests that these cells may have special immunologic properties that may allow transplantation between individuals or even between species without rejection or the need for toxic immunosuppressive drugs," added Dr. Flake.

Collaborating with Dr. Flake in the study was Kenneth W. Liechty, M.D., of Children’s Hospital. Other co-authors were from Children’s Hospital and from Osiris Therapeutics of Baltimore, Maryland, a biotechnology company.

Founded in 1855 as the nation’s first pediatric hospital, The Children’s Hospital of Philadelphia is recognized today as one of the leading treatment and research facilities in the world. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children’s Hospital has fostered discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique outreach and public service programs have brought the 381-bed hospital recognition as a leading advocate for children from before birth through age 19.


Story Source:

The above story is based on materials provided by The Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


Cite This Page:

The Children's Hospital of Philadelphia. "Transplanted Human Stem Cells Develop into Broad Range of Tissues, Persist over a Year in Research at The Children's Hospital of Philadelphia." ScienceDaily. ScienceDaily, 1 November 2000. <www.sciencedaily.com/releases/2000/10/001030164628.htm>.
The Children's Hospital of Philadelphia. (2000, November 1). Transplanted Human Stem Cells Develop into Broad Range of Tissues, Persist over a Year in Research at The Children's Hospital of Philadelphia. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2000/10/001030164628.htm
The Children's Hospital of Philadelphia. "Transplanted Human Stem Cells Develop into Broad Range of Tissues, Persist over a Year in Research at The Children's Hospital of Philadelphia." ScienceDaily. www.sciencedaily.com/releases/2000/10/001030164628.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins