Featured Research

from universities, journals, and other organizations

Study Finds Serious Bone Loss In 90 Percent Of Women With Anorexia

Date:
November 27, 2000
Source:
Massachusetts General Hospital
Summary:
More than 90 percent of young women with anorexia nervosa were found to have significant bone loss in a study conducted at Massachusetts General Hospital (MGH). The report, appearing in the November 21 issue of Annals of Internal Medicine, also found that taking estrogen did not seem to reduce the risk of bone loss.

More than 90 percent of young women with anorexia nervosa were found to have significant bone loss in a study conducted at Massachusetts General Hospital (MGH). The report, appearing in the November 21 issue of Annals of Internal Medicine, also found that taking estrogen did not seem to reduce the risk of bone loss.

Related Articles


"While it is well known that bone loss is a significant problem for women with anorexia, this study shows how extensive the problem is and characterizes factors that predict bone loss," says Steven Grinspoon, MD, the paper's lead author, who is on the staff of the MGH Neuroendocrine Unit. "It also shows that regaining and maintaining a healthy weight is key to preventing or reducing bone loss."

David Herzog, MD, director of the MGH Eating Disorders Clinic and a study co-author, adds, "Anorexia and its associated bone loss are very serious medical problems that present difficult challenges to both patients and the clinicians who care for them. We hope one result of this study will be to help motivate women with anorexia to get the treatment they need."

Patients with anorexia nervosa - an extreme loss of weight associated with seriously restricting food intake, an unrealistic fear of weight gain and a distorted body image - are at risk for a number of serious, even life-threatening health problems. A loss of menstrual periods, associated with disruption of normal levels of estrogen and other hormones, is a hallmark of anorexia in women. Loss of bone mass, sometimes leading to fractures, is a significant complication in most women with anorexia, but it was not previously known whether that bone loss resulted primarily from the estrogen deficiency or from overall malnutrition.

The study enrolled 130 women in their mid-20s with anorexia nervosa, most of whom did not have normal menstrual periods. Some participants had resumed periods while taking supplemental estrogen, primarily in the form of birth control pills. Participants all were living in their communities, not hospitalized for treatment of their illness. The research team gathered detailed histories and measurements on the participants - including menstrual history, estrogen use history, fracture history and frame size - before conducting bone density measurements of the spine and hip.

The results showed that 92 percent of study participants had significant bone loss (osteopenia) in at least one of the sites measured, and 38 percent of participants had bone loss serious enough to meet World Health Organization criteria for osteoporosis. Broken down by site of measurement, more than 50 percent of the women had osteopenia at the spine and almost 25 percent had osteoporosis; and 47 percent had osteopenia measured at the hip with 16 percent having osteoporosis.

Of numerous other variables recorded, weight was the most powerful predictor of bone loss at all sites, with those women who weighed the least showing the most serious bone loss. Menstrual history also correlated with spinal bone density, suggesting that estrogen deficiency plays a greater relative role in spinal bone loss than in loss at other sites. Current estrogen use was reported in 23 percent of participants and previous estrogen use reported in 58 percent of participants. However, estrogen use had no effect on bone density at any of the sites measured. Use of calcium or Vitamin D supplements similarly had no effect.

Anne Klibanski, MD, director of the MGH Neuroendocrine Unit and the study's principal investigator, says, "Some of these young women are experiencing bone loss comparable to that of women many decades older, despite estrogen therapy. Given this severity and the prevalence of bone loss, the importance of screening all women with anorexia for osteoporosis cannot be over-emphasized. Other studies have shown that some degree of bone loss in anorexia may be permanent, so it will be critical to develop new therapies to prevent and treat bone loss in these women."

The study's other co-authors are Elizabeth Thomas, NP, Sarah Pitts, Erin Gross, and Karen Miller, MD, of the MGH Neuroendocrine Unit and Diane Mickley, MD, of the Wilkins Center for Eating Disorders in Greenwich, Conn. The research was supported by grants from the National Institutes of Health, the Rubenstein Foundation and the Harvard Eating Disorders Center.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Study Finds Serious Bone Loss In 90 Percent Of Women With Anorexia." ScienceDaily. ScienceDaily, 27 November 2000. <www.sciencedaily.com/releases/2000/11/001122181117.htm>.
Massachusetts General Hospital. (2000, November 27). Study Finds Serious Bone Loss In 90 Percent Of Women With Anorexia. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2000/11/001122181117.htm
Massachusetts General Hospital. "Study Finds Serious Bone Loss In 90 Percent Of Women With Anorexia." ScienceDaily. www.sciencedaily.com/releases/2000/11/001122181117.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins