Featured Research

from universities, journals, and other organizations

Study Ties Gene To Faster Progression Of Multiple Sclerosis Symptoms

Date:
February 16, 2001
Source:
American Academy Of Neurology
Summary:
Multiple sclerosis patients who were carriers of the APOE, or apolipoprotein E, gene are more likely to experience faster progression of disability from the disease, according to a study reported in Neurology, the scientific journal of the American Academy of Neurology.

Multiple sclerosis patients who were carriers of the APOE, or apolipoprotein E, gene are more likely to experience faster progression of disability from the disease, according to a study reported in Neurology, the scientific journal of the American Academy of Neurology.

Related Articles


MS is a chronic inflammatory disease of the central nervous system characterized by flare-ups followed by remissions. APOE, important in lipid transport, also acts as a factor in nerve growth, and may advance the disease’s disabling symptoms. There are three common varieties of APOE and the APOE 4 allele has been consistently associated with an increased risk of Alzheimer’s disease.

The study of the linkage between the APOE gene and MS progression was one of the largest to date, including 205 MS patients, 41 with the APOE gene, and 164 without. The appearance of the gene in the study subjects was consistent with the frequency it is found in the general population.

Tests to measure disability status were performed every three to six months, beginning with the time of onset of the disease, and at five and 10 years following onset. According to study author Amos D. Korczyn, a neurologist at Tel Aviv University in Israel, there was a trend toward higher disability among the APOE group at five years, but the difference increased significantly at 10 years. “The proportion of patients considered to have progressive forms of MS was significantly higher among APOE carriers,” Korczyn said.

The presence of the APOE gene also coincided with earlier onset of the disease. The average age of onset of the disease was 31.8 years old, while those without the APOE had an average onset age of 35.1.

The American Academy of Neurology, an association of more than 17,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research.

For more information about the American Academy of Neurology, visit its Web site at http://www.aan.com.


Story Source:

The above story is based on materials provided by American Academy Of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy Of Neurology. "Study Ties Gene To Faster Progression Of Multiple Sclerosis Symptoms." ScienceDaily. ScienceDaily, 16 February 2001. <www.sciencedaily.com/releases/2001/02/010214075159.htm>.
American Academy Of Neurology. (2001, February 16). Study Ties Gene To Faster Progression Of Multiple Sclerosis Symptoms. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2001/02/010214075159.htm
American Academy Of Neurology. "Study Ties Gene To Faster Progression Of Multiple Sclerosis Symptoms." ScienceDaily. www.sciencedaily.com/releases/2001/02/010214075159.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins