Featured Research

from universities, journals, and other organizations

Genetically Engineered Skin Substitute Is Designed To Promote Wound Healing

Date:
April 4, 2001
Source:
University At Buffalo
Summary:
Bioengineers at the University at Buffalo and Shriners Burns Hospital-Boston have created a genetically engineered skin that expresses a protein that promotes wound healing. It is believed to be the only artificial tissue designed to express keratinocyte growth factor, KGF.

BUFFALO, N.Y. -- Bioengineers at the University at Buffalo and Shriners Burns Hospital-Boston have created a genetically engineered skin that expresses a protein that promotes wound healing. It is believed to be the only artificial tissue designed to express keratinocyte growth factor, KGF.

Their research, published today (April 1, 2001) in the FASEB Journal of the Federation of American Societies of Experimental Biology, suggests that a skin substitute could be developed that would accelerate the generation of new skin following severe injuries or burns. Currently, there is no FDA-approved skin substitute for treating burns.

The research demonstrates for the first time that a growth factor can bring about significant changes in the three-dimensional organization and function of a skin equivalent in vitro.

Stelios T. Andreadis, Ph.D., assistant professor in the UB Department of Chemical Engineering, director of the UB Bioengineering Laboratory and lead author on the paper, said the researchers have submitted a grant proposal for animal studies aimed at confirming whether the artificial skin would have a therapeutic effect.

The co-authors are Karen E. Hamoen, Martin L. Yarmush and Jeffrey Morgan, all of Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital-Boston.

"Our goal was to create genetically modified skin equivalents that secrete keratinocyte growth factor as a means to accelerate wound healing," said Andreadis.

"We also wanted to create a model system to study the effects of this protein on the development and morphogenesis of engineered skin tissues."

Andreadis said the presence of KGF "appears to have profound effects on wound healing, by spurring the proliferation of skin cells."

He added that the genetically modified tissue substitute has a number of advantages that make it a good candidate for a skin substitute.

"What's significant about our substitute is that it contains the basement membrane -- the matrix molecules that the cells of the epidermis like to sit on -- that retains the natural composition and topography of skin," he added.

The genetically engineered skin also has high mechanical stability and is pliable, important advantages over skins made from collagen gels, which, he said, have a consistency similar to that of gelatin and therefore are much more difficult to use.

Most important, Andreadis explained, the engineered tissue has good barrier function, preventing dehydration and protecting against pathogens.

"This is very important for burn patients who have lost a substantial fraction of their total body surface area and who suffer from excessive dehydration and bacterial infections," he said. "Because they are very much like real skin, the engineered cell-based skin equivalents can provide these functions."


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Genetically Engineered Skin Substitute Is Designed To Promote Wound Healing." ScienceDaily. ScienceDaily, 4 April 2001. <www.sciencedaily.com/releases/2001/04/010402073217.htm>.
University At Buffalo. (2001, April 4). Genetically Engineered Skin Substitute Is Designed To Promote Wound Healing. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2001/04/010402073217.htm
University At Buffalo. "Genetically Engineered Skin Substitute Is Designed To Promote Wound Healing." ScienceDaily. www.sciencedaily.com/releases/2001/04/010402073217.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins