Featured Research

from universities, journals, and other organizations

Reduced Nitric Oxide In Blood Linked To Preeclampsia

Date:
June 14, 2001
Source:
American Heart Association
Summary:
Researchers have identified reduced blood levels of available nitric oxide as a cause of preeclampsia – a life-threatening condition that causes, among other things, high blood pressure during pregnancy, according to a report in the June 8 issue of Circulation Research: Journal of the American Heart Association.

DALLAS, June 8 – Researchers have identified reduced blood levels of available nitric oxide as a cause of preeclampsia – a life-threatening condition that causes, among other things, high blood pressure during pregnancy, according to a report in the June 8 issue of Circulation Research: Journal of the American Heart Association.

Preeclampsia is a major cause of severe complications and death for both mother and newborn. Nitric oxide (NO) is produced by the blood vessels and helps the vessels relax, which eases blood pressure.

Researchers took blood samples from 21 pregnant women with preeclampsia and 21 women with normal pregnancies. Those with preeclampsia had elevated blood levels of S-nitrosothiols, substances that act as a major reservoir of releasable NO, which means NO was not being released. The levels of S-nitrosothiols were 294 picomole per milligram (pmol/mg) of protein in women with preeclampsia vs.186 pmol/mg in those with healthy pregnancies. A substance called S-nitrosoalbumin, a type of S-nitrosothiol formed from albumin (the most abundant protein in blood plasma), was the major contributor to the elevated levels of S-nitrosothiols in preeclampsia. Its levels were significantly higher in preeclamptic than in normal pregnant or nonpregnant women (256, 137, and 94 pmol/mg protein, respectively).

The increases in these substances in preeclamptic women may reflect insufficient release of NO, an important physiological regulator of blood pressure. Further studies are needed to test whether antioxidant vitamins, particularly vitamin C, which seems to reduce the incidence of preeclampsia, might also enhance the release of NO from S-nitrosothiols.

This research was funded in part from the National Institutes of Health.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Reduced Nitric Oxide In Blood Linked To Preeclampsia." ScienceDaily. ScienceDaily, 14 June 2001. <www.sciencedaily.com/releases/2001/06/010611072928.htm>.
American Heart Association. (2001, June 14). Reduced Nitric Oxide In Blood Linked To Preeclampsia. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2001/06/010611072928.htm
American Heart Association. "Reduced Nitric Oxide In Blood Linked To Preeclampsia." ScienceDaily. www.sciencedaily.com/releases/2001/06/010611072928.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins