Featured Research

from universities, journals, and other organizations

Reduced Nitric Oxide In Blood Linked To Preeclampsia

Date:
June 14, 2001
Source:
American Heart Association
Summary:
Researchers have identified reduced blood levels of available nitric oxide as a cause of preeclampsia – a life-threatening condition that causes, among other things, high blood pressure during pregnancy, according to a report in the June 8 issue of Circulation Research: Journal of the American Heart Association.

DALLAS, June 8 – Researchers have identified reduced blood levels of available nitric oxide as a cause of preeclampsia – a life-threatening condition that causes, among other things, high blood pressure during pregnancy, according to a report in the June 8 issue of Circulation Research: Journal of the American Heart Association.

Preeclampsia is a major cause of severe complications and death for both mother and newborn. Nitric oxide (NO) is produced by the blood vessels and helps the vessels relax, which eases blood pressure.

Researchers took blood samples from 21 pregnant women with preeclampsia and 21 women with normal pregnancies. Those with preeclampsia had elevated blood levels of S-nitrosothiols, substances that act as a major reservoir of releasable NO, which means NO was not being released. The levels of S-nitrosothiols were 294 picomole per milligram (pmol/mg) of protein in women with preeclampsia vs.186 pmol/mg in those with healthy pregnancies. A substance called S-nitrosoalbumin, a type of S-nitrosothiol formed from albumin (the most abundant protein in blood plasma), was the major contributor to the elevated levels of S-nitrosothiols in preeclampsia. Its levels were significantly higher in preeclamptic than in normal pregnant or nonpregnant women (256, 137, and 94 pmol/mg protein, respectively).

The increases in these substances in preeclamptic women may reflect insufficient release of NO, an important physiological regulator of blood pressure. Further studies are needed to test whether antioxidant vitamins, particularly vitamin C, which seems to reduce the incidence of preeclampsia, might also enhance the release of NO from S-nitrosothiols.

This research was funded in part from the National Institutes of Health.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Reduced Nitric Oxide In Blood Linked To Preeclampsia." ScienceDaily. ScienceDaily, 14 June 2001. <www.sciencedaily.com/releases/2001/06/010611072928.htm>.
American Heart Association. (2001, June 14). Reduced Nitric Oxide In Blood Linked To Preeclampsia. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2001/06/010611072928.htm
American Heart Association. "Reduced Nitric Oxide In Blood Linked To Preeclampsia." ScienceDaily. www.sciencedaily.com/releases/2001/06/010611072928.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins