Featured Research

from universities, journals, and other organizations

Reduced Nitric Oxide In Blood Linked To Preeclampsia

Date:
June 14, 2001
Source:
American Heart Association
Summary:
Researchers have identified reduced blood levels of available nitric oxide as a cause of preeclampsia – a life-threatening condition that causes, among other things, high blood pressure during pregnancy, according to a report in the June 8 issue of Circulation Research: Journal of the American Heart Association.

DALLAS, June 8 – Researchers have identified reduced blood levels of available nitric oxide as a cause of preeclampsia – a life-threatening condition that causes, among other things, high blood pressure during pregnancy, according to a report in the June 8 issue of Circulation Research: Journal of the American Heart Association.

Related Articles


Preeclampsia is a major cause of severe complications and death for both mother and newborn. Nitric oxide (NO) is produced by the blood vessels and helps the vessels relax, which eases blood pressure.

Researchers took blood samples from 21 pregnant women with preeclampsia and 21 women with normal pregnancies. Those with preeclampsia had elevated blood levels of S-nitrosothiols, substances that act as a major reservoir of releasable NO, which means NO was not being released. The levels of S-nitrosothiols were 294 picomole per milligram (pmol/mg) of protein in women with preeclampsia vs.186 pmol/mg in those with healthy pregnancies. A substance called S-nitrosoalbumin, a type of S-nitrosothiol formed from albumin (the most abundant protein in blood plasma), was the major contributor to the elevated levels of S-nitrosothiols in preeclampsia. Its levels were significantly higher in preeclamptic than in normal pregnant or nonpregnant women (256, 137, and 94 pmol/mg protein, respectively).

The increases in these substances in preeclamptic women may reflect insufficient release of NO, an important physiological regulator of blood pressure. Further studies are needed to test whether antioxidant vitamins, particularly vitamin C, which seems to reduce the incidence of preeclampsia, might also enhance the release of NO from S-nitrosothiols.

This research was funded in part from the National Institutes of Health.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Reduced Nitric Oxide In Blood Linked To Preeclampsia." ScienceDaily. ScienceDaily, 14 June 2001. <www.sciencedaily.com/releases/2001/06/010611072928.htm>.
American Heart Association. (2001, June 14). Reduced Nitric Oxide In Blood Linked To Preeclampsia. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2001/06/010611072928.htm
American Heart Association. "Reduced Nitric Oxide In Blood Linked To Preeclampsia." ScienceDaily. www.sciencedaily.com/releases/2001/06/010611072928.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins