Featured Research

from universities, journals, and other organizations

Umbilical Cord Blood Transplant: Effective New Leukemia Treatment For Adults

Date:
June 19, 2001
Source:
University Hospitals Of Cleveland
Summary:
In the first published study of its kind, researchers at the Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University have demonstrated the successful use of umbilical cord blood in the treatment of adults suffering from life-threatening forms of leukemia or aplastic anemia.

CLEVELAND -- In the first published study of its kind, researchers at the Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University have demonstrated the successful use of umbilical cord blood in the treatment of adults suffering from life-threatening forms of leukemia or aplastic anemia.

As detailed in the June 14th issue of The New England Journal of Medicine, a team led by Mary J. Laughlin, MD, showed that the transplantation of cord blood following high dose chemotherapy and radiation, can save the lives of about one-third of adult patients for whom other treatments are likely to fail.

“The patients we studied were unable to find a suitable bone marrow match among family members or donors in the nationwide bone marrow bank,” explains Dr. Laughlin, director of allogeneic transplantation at University Hospitals Ireland Cancer Center and assistant professor of medicine at CWRU. “We have shown that umbilical cord blood, which is rich in stem cells necessary for a successful transplantation, is a viable alternative for these patients, and the cord blood used does not have to be an exact match to be effective.”

Umbilical cord blood is retrieved from the placenta after the birth of a child. While normally the cord and placenta is discarded after birth, the cord blood can be saved, frozen and stored. The stem cells in the cord blood are immature blood-forming cells, a component of bone marrow, capable of maturing into red blood cells, platelets, or infection-fighting white blood cells. When transplanted into a cancer patient whose own bone marrow has been depleted after chemotherapy or radiation treatments, these stem cells provide the basis for a new healthy-blood forming immune system.

“For years, we’ve been able to use cord blood successfully to treat children with leukemia and other blood disorders. But researchers have wondered whether the small amount of stem cells in cord blood can create a whole new immune system in fully-grown adults, who are also more likely than children to reject a less-than-perfect transplant,” says Dr. Laughlin. “We’ve been able to show that just two ounces of blood harvested from an umbilical cord can generate a new blood-producing immune system, and we don’t even need a perfect match for a successful transplant because of the immature nature of cord blood stem cells.”

Dr. Laughlin and her colleagues conducted a retrospective study of 68 adults, ages 18 to 58, all of whom had received either intensive chemotherapy or total-body radiation to deplete their bone marrow. Following transplantation with cord blood, 90% of patients experienced the growth of new, healthy blood cells. The incidence of graft-versus-host disease (GVHD) was lower than expected, but still the cause of significant complications and mortality in many patients. Of the 68 patients who underwent transplantation with cord blood, 19 were alive (18 of those completely disease-free) at 40 months.

With support from The Leukemia & Lymphoma Society, Dr. Laughlin is continuing to work with cord blood stem cells in the laboratory, to grow them in vivo, hoping that a larger dose of stem cells used in transplant will cause blood counts to recover faster and lower the risk of infections. She is also trying to understand why umbilical cord blood is less likely to be “rejected” by the recipient after transplantation.

The Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University is a Comprehensive Cancer Center designated by the National Cancer Institute, the only NCI/CCC in northern Ohio. It is one of few centers in the country actively using umbilical cord blood in the transplantation of adults with blood disorders and cancers.


Story Source:

The above story is based on materials provided by University Hospitals Of Cleveland. Note: Materials may be edited for content and length.


Cite This Page:

University Hospitals Of Cleveland. "Umbilical Cord Blood Transplant: Effective New Leukemia Treatment For Adults." ScienceDaily. ScienceDaily, 19 June 2001. <www.sciencedaily.com/releases/2001/06/010614064016.htm>.
University Hospitals Of Cleveland. (2001, June 19). Umbilical Cord Blood Transplant: Effective New Leukemia Treatment For Adults. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2001/06/010614064016.htm
University Hospitals Of Cleveland. "Umbilical Cord Blood Transplant: Effective New Leukemia Treatment For Adults." ScienceDaily. www.sciencedaily.com/releases/2001/06/010614064016.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins