Featured Research

from universities, journals, and other organizations

Genetic Mutation May Be Key To Onset Of Deadly Skin Cancer

Date:
August 16, 2001
Source:
Johns Hopkins Medical Institutions
Summary:
A Johns Hopkins scientist and a team of collaborators have discovered how precancerous moles may progress to melanomas, the most deadly type of skin cancer. The preliminary report, in the August 15 issue of Cancer Research, describes a link between two genes that trigger skin cancers and could serve as early diagnostic markers for the disease.

A Johns Hopkins scientist and a team of collaborators have discovered how precancerous moles may progress to melanomas, the most deadly type of skin cancer. The preliminary report, in the August 15 issue of Cancer Research, describes a link between two genes that trigger skin cancers and could serve as early diagnostic markers for the disease. The researchers say that, in melanomas, a cell growth regulatory gene known as Id1 deactivates an important tumor suppressor gene (p16/Ink4a), allowing cancer cells to grow uncontrollably.* High levels of Id1 proteins are found only in the first stages of melanoma, allowing it to be detected and treated while still in a curable stage. trigger skin cancers and could serve as early diagnostic markers for the disease.

Related Articles


“Telling the difference between precancerous moles and early-stage melanoma can be very difficult, and the treatments for these two lesions differ significantly,” explains Rhoda Alani, M.D., assistant professor of oncology, dermatology, molecular biology and genetics and director of the study. “If it’s melanoma, you want to catch it very early and treat it aggressively by removing as much tissue as possible to cure the disease.” Since Id1 is expressed in early-stage melanoma, it has the potential to serve as a definitive diagnostic marker although more studies are needed to confirm this use.trigger skin cancers and could serve as early diagnostic markers for the disease.

The scientists studied Id1 protein expression in 21 tissue samples from a variety of skin cancers, including normal non-cancerous moles (benign nevus), precancerous moles (dysplastic nevus), early-stage melanoma (in-situ melanoma), invasive melanoma and metastatic melanoma. “We found high levels of Id1 activity in the earliest phases of melanoma, when it’s limited to the top layer of the skin (or epidermis). Precancerous moles, invasive and metastatic melanomas do not express high levels of Id1,” reports Alani. Larger studies are planned.trigger skin cancers and could serve as early diagnostic markers for the disease.

The scientists speculate that while the Id1 gene shuts off p16/Ink4a in early melanomas and lifts the brake on uncontrolled cancer cell growth, various mutations or other DNA changes must also occur to the p16/Ink4a gene to damage it beyond repair. So, as the cancer progresses, Id1 becomes less important for shutting off the gene. “This may explain why we see lower expression of Id1 in more advanced melanomas,” says Alani.trigger skin cancers and could serve as early diagnostic markers for the disease.

Melanoma can progress very rapidly and spread to other parts of the body. When treated early, the chance for cure is very high. Only 12 percent of people with metastatic melanoma survive beyond five years.trigger skin cancers and could serve as early diagnostic markers for the disease.

Melanoma will strike 51,400 people in the United States this year, and 7,800 will die from the disease.trigger skin cancers and could serve as early diagnostic markers for the disease.

In addition to Alani, other participants in this research include David Polsky from NYU Medical Center; Alison Zuyung Young and Klaus J. Busam from Memorial Sloan-Kettering Cancer Center. This research was funded by The National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS).trigger skin cancers and could serve as early diagnostic markers for the disease.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Genetic Mutation May Be Key To Onset Of Deadly Skin Cancer." ScienceDaily. ScienceDaily, 16 August 2001. <www.sciencedaily.com/releases/2001/08/010815082241.htm>.
Johns Hopkins Medical Institutions. (2001, August 16). Genetic Mutation May Be Key To Onset Of Deadly Skin Cancer. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2001/08/010815082241.htm
Johns Hopkins Medical Institutions. "Genetic Mutation May Be Key To Onset Of Deadly Skin Cancer." ScienceDaily. www.sciencedaily.com/releases/2001/08/010815082241.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins