Featured Research

from universities, journals, and other organizations

Initial Results Promising For MIT Breast Cancer Treatment

Date:
September 20, 2001
Source:
Massachusetts Institute Of Technology
Summary:
A breast-cancer treatment based on MIT radar research is now in Phase II clinical trials, and preliminary results to be reported at a September 24 meeting look promising.

CAMBRIDGE, Mass. -- A breast-cancer treatment based on MIT radar research is now in Phase II clinical trials, and preliminary results to be reported at a September 24 meeting look promising.

In the treatment, microwave radiation is focused externally on the breast, heating and killing tumor cells within. "After thermotherapy treatment, we are seeing significant breast cancer cell kill without damage to the skin," said Dr. Robert A. Gardner, MD, of the initial Phase II results. Gardner is a breast surgeon at Columbia Hospital’s Center for Breast Care in West Palm Beach, Florida, one of three hospitals currently participating in the trials.

At the 24th International Congress on Clinical Hyperthermia in Rome, Italy, September 24-29, Gardner and other clinical researchers involved in the study will present the results for thermotherapy of four women with early-stage breast cancer. The Phase II trial should be completed in 2002 with the treatment of 39 other women at Columbia Hospital, Martin Luther University in Halle, Germany, and Harbor-UCLA Medical Center in California.

A second Phase II trial for 90 patients with locally advanced breast cancer should begin this month at Columbia Hospital. Martin Luther University is also accepting patients. This trial, too, is expected to be completed in 2002.

Celsion Corporation (Columbia, Maryland) exclusively licenses the technology from MIT. The company has developed the clinical thermotherapy system and is funding the clinical studies.

The technology itself was invented by Dr. Alan J. Fenn, senior staff member in the Sensor Systems Division at MIT Lincoln Laboratory. It is based on space-borne radar technology Fenn originally developed to detect missiles and nullify enemy jamming.

"The adaptively focused microwave radiation used in the technique avoids heating the skin, and selectively heats -- and kills – cancer cells spread within a large region of the breast," Fenn said.

Due to both higher water and ion contents, breast cancer cells absorb about two to four times more microwave energy than healthy breast tissue, destroying the cancer.

If the thermotherapy technique can destroy breast cancer cells, breast surgery could be reduced or eliminated. There is also the potential to reduce or eliminate conventional x-ray radiation. Surgery, x-ray radiation, and chemotherapy have significant side effects and do not always eliminate all of the cancer cells.

The goal of the Phase II study treating women with early-stage breast cancer is to demonstrate the potential benefits of destroying the cancer prior to breast conservation therapy (lumpectomy and x-ray radiation).

The women with locally advanced breast cancer in the second Phase II study will receive both preoperative microwave thermotherapy and preoperative chemotherapy treatments. The goal is to more effectively destroy breast cancer cells and shrink the tumor to decrease the need for mastectomy. The randomized study will compare results from preoperative thermochemotherapy to preoperative chemotherapy alone. The first patient in this study is scheduled to be treated at Columbia Hospital this month by Gardner.

Principal investigators for the Phase II clinical trials are Gardner at Columbia Hospital; Sylvia H. Heywang-K๖brunner, MD, of Martin Luther University; and Hernan I. Vargas, MD, of Harbor-UCLA.

The Department of the Air Force funded the original MIT Lincoln Laboratory research by Fenn. An article by Fenn and colleagues about the adaptive microwave phased array radar technology was published in a recent issue of the MIT Lincoln Laboratory Journal.


Story Source:

The above story is based on materials provided by Massachusetts Institute Of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts Institute Of Technology. "Initial Results Promising For MIT Breast Cancer Treatment." ScienceDaily. ScienceDaily, 20 September 2001. <www.sciencedaily.com/releases/2001/09/010920072015.htm>.
Massachusetts Institute Of Technology. (2001, September 20). Initial Results Promising For MIT Breast Cancer Treatment. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2001/09/010920072015.htm
Massachusetts Institute Of Technology. "Initial Results Promising For MIT Breast Cancer Treatment." ScienceDaily. www.sciencedaily.com/releases/2001/09/010920072015.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins