Featured Research

from universities, journals, and other organizations

Researchers Investigate Genes In Cancer Resistance

Date:
January 28, 2002
Source:
University Of Toronto
Summary:
Studies on genetic resistance to certain types of cancer in rats are helping University of Toronto researchers learn more about cancer resistance in humans, according to an article in the January issue of the journal Carcinogenesis.

Studies on genetic resistance to certain types of cancer in rats are helping University of Toronto researchers learn more about cancer resistance in humans, according to an article in the January issue of the journal Carcinogenesis.

"While scientists have already identified some genes that give people an inherited predisposition to cancer, there has been little research on inherited resistance to cancer," says Michael Archer, the studies' principal investigator and a professor of medical biophysics in the Faculty of Medicine. Since cancer resistance is "invisible," it is extremely difficult to identify in humans and animal models must be used. Researchers have found some strains of rats are highly resistant to specific cancers, and Archer's lab has discovered the precise cellular mechanisms that confer this resistance. In addition to finding that the mechanism of resistance seems to be similar in different resistant tissues, he has made some surprising discoveries about the cellular processes involved. "When cancer-causing agents are introduced into the rats' bodies, the animals develop pre-cancerous lesions but then, over a period of time, the cells return to normal," he says.

With this information, he and his colleagues are now trying to identify the genes, called tumour-modifier genes, involved in the rats' resistance to cancer. "We anticipate that knowledge of the rodent genes will facilitate identification of human genes involved in resistance that will have potentially important applications in cancer prevention and therapy," says Archer, also chair of the nutritional sciences department. There is a lot of work to be done before these findings can be applied to human cancer, but Archer says the results are promising. "Any advance in our understanding of cancer development - whether it's of genes that lead to cancer or of genes that make people resistant to cancer - is important and offers the potential to manipulate the genes for our benefit."

Archer's research is supported by the Canadian Breast Cancer Research Initiative.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Researchers Investigate Genes In Cancer Resistance." ScienceDaily. ScienceDaily, 28 January 2002. <www.sciencedaily.com/releases/2002/01/020123080412.htm>.
University Of Toronto. (2002, January 28). Researchers Investigate Genes In Cancer Resistance. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2002/01/020123080412.htm
University Of Toronto. "Researchers Investigate Genes In Cancer Resistance." ScienceDaily. www.sciencedaily.com/releases/2002/01/020123080412.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins