Featured Research

from universities, journals, and other organizations

Antidepressant Provides A Cool Choice For Hot Flashes

Date:
February 14, 2002
Source:
Mayo Clinic
Summary:
A Mayo Clinic study indicates long-term use of the antidepressant drug venlafaxine provides women treated for breast cancer with safe and effective relief from hot flashes. It also appears that this antidepressant can be an alternative to estrogen for women who want a nonhormonal treatment for their hot flashes.

ROCHESTER, MINN. -- A Mayo Clinic study indicates long-term use of the antidepressant drug venlafaxine provides women treated for breast cancer with safe and effective relief from hot flashes. It also appears that this antidepressant can be an alternative to estrogen for women who want a nonhormonal treatment for their hot flashes.

Related Articles


This follow-up study showed that women receiving venlafaxine over eight weeks maintained approximately a 60 percent reduction in their hot flashes. A total of 102 postmenopausal women participated in this investigation. The findings of the eight-week evaluation mirrored the results of the first phase of this study -- a four-week double-blinded, randomized study that involved more than 200 women.

The results of the study are published in the current edition of Oncology Nursing Forum.

“The clear message is that now many women with breast cancer do not have to suffer with their hot flashes and that women who want a non-estrogenic choice of treatment now have one,” says Charles Loprinzi, M.D., a Mayo Clinic oncologist.

“The study also further reassures physicians and other health care providers that venlafaxine is a safe and effective nonhormonal treatment they can consider for their postmenopausal patients.”

Dr. Loprinzi co-authored this study with Debra L. Barton, Ph.D., a Mayo Clinic oncology nurse researcher.

“We know from our previous study that venlafaxine works in the short term to control hot flashes,” says Dr. Barton. “This follow-up study provides evidence that venlafaxine continues to be effective and well tolerated over a longer period of time.”

Hot flashes are a major problem for many postmenopausal women. In women without breast cancer, hormone replacement therapy involving estrogen is the typical treatment prescribed to relieve the problem.

That is not the case for women with breast cancer. Frequently, the chemotherapy used to treat the cancer causes the woman to go into early menopause and experience severe hot flashes. Because of the concern that estrogen may lead to the growth of breast cancer cells, these women are often denied estrogen for hot flashes.

The newer antidepressants, of which venlafaxine is one, offer more hope for nonhormonal management of hot flashes. These newer antidepressants work to control various neurotransmitters in the brain. Some of those neurotransmitters are thought to trigger hot flashes.

“In a dose of 75 mg per day, extended-release venlafaxine offered an average 60 percent reduction in the frequency of hot flashes,” says Dr. Loprinzi. “Women in both studies also noted that venlafaxine seemed to reduce the severity of their hot flashes.”

The side effects of venlafaxine include mild appetite loss, dry mouth and, in some women, nausea. Of the minority of women in this study experiencing nausea from venlafaxine, most rated their nausea as relatively mild and transitory. In about 10 percent of the women, nausea was a more prominent problem.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Antidepressant Provides A Cool Choice For Hot Flashes." ScienceDaily. ScienceDaily, 14 February 2002. <www.sciencedaily.com/releases/2002/02/020213074150.htm>.
Mayo Clinic. (2002, February 14). Antidepressant Provides A Cool Choice For Hot Flashes. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2002/02/020213074150.htm
Mayo Clinic. "Antidepressant Provides A Cool Choice For Hot Flashes." ScienceDaily. www.sciencedaily.com/releases/2002/02/020213074150.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins