Featured Research

from universities, journals, and other organizations

Genetic Connection In Link Between Permanent Hair Dye Use And Bladder Cancer Risk

Date:
April 10, 2002
Source:
University Of Southern California
Summary:
Certain women may be more susceptible to bladder cancer associated with the use of permanent hair dyes than other women, based on their genetic makeup, according to study results released by researchers at the Keck School of Medicine of USC and colleagues.

SAN FRANCISCO, April 9 -- Certain women may be more susceptible to bladder cancer associated with the use of permanent hair dyes than other women, based on their genetic makeup, according to study results released today by researchers at the Keck School of Medicine of the University of Southern California and colleagues. Female study participants whose bodies could only slowly flush out carcinogens known as arylamines, which are an ingredient of hair dye, had a higher risk of bladder cancer than women whose bodies eliminated the carcinogens more quickly, the investigators reported. The body's efficiency in removing such toxins depends on whether someone possesses the "fast" or "slow" version of certain key genes.

Researchers presented results at the American Association of Cancer Research's 93rd Annual Meeting.

"We believe these results provide further evidence supporting a causal association between permanent hair dye use and bladder cancer risk," said Manuela Gago-Dominguez, M.D., Ph.D., researcher in preventive medicine at the Keck School and USC/Norris Comprehensive Cancer Center and lead author of the study. "They implicate the arylamines contained in hair dye solutions as the carcinogenic substances responsible for bladder cancer development in the users of these dyes." Early in 2001, USC preventive medicine researchers reported that women who use permanent dyes at least once a month for one year or longer have twice the risk of bladder cancer as non-users. Monthly or more frequent users of 15 or more years experience three times that risk even after adjusting for smoking, a known risk factor for bladder cancer.

The increase in bladder cancer risk also was observed in people who are exposed to hair dyes in their work, such as barbers and hairdressers. Increased risk was not seen for those who used temporary or semi-permanent dyes.

Gago-Dominguez explained that small amounts of arylamines are absorbed through the skin during the use of hair dye. Certain agents contained in permanent dye might cause more of the arylamines to be absorbed through the skin than in the case of temporary or semi-permanent dyes, some theorize.

Certain important, protective enzymes in the body metabolize those arylamines, trying to render them harmless. The body expels the chemicals through urine, which passes through the bladder. The efficiency of these protective enzymes depends on genes that provide the recipe for making the enzymes. The genes come in fast and slow varieties.

The research team looked at 159 female bladder cancer patients in Los Angeles and compared them to 164 similar, healthy women, analyzing their genetic makeup through blood and urine samples. They found that in women with certain slow genes (the "NAT2 slow" phenotype), exclusive permanent hair dye use was associated with a nearly tripled risk of bladder cancer.

Among women with other slow genes (the "CYP1A2 slow" phenotype), exclusive permanent hair dye use was associated with a 2.5-fold increased risk. Finally, among non-smoking women with a third type of slow genes ("NAT1 slow" genotype), exclusive permanent hair dye use was associated with a 6.8-fold increased risk.

Further study is needed to fully understand relationships between hair dyes and bladder cancer, researchers said.

Bladder cancer currently accounts for 6 percent of all new cancer cases in men and 2 percent of all new cancer cases in women. The American Cancer Society estimates that 56,500 Americans will be diagnosed with the cancer and 12,600 Americans will die from it in 2002. The research was supported by grants from the National Cancer Institute and the National Institute of Environmental Health Sciences (NIEHS).


Story Source:

The above story is based on materials provided by University Of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University Of Southern California. "Genetic Connection In Link Between Permanent Hair Dye Use And Bladder Cancer Risk." ScienceDaily. ScienceDaily, 10 April 2002. <www.sciencedaily.com/releases/2002/04/020410075652.htm>.
University Of Southern California. (2002, April 10). Genetic Connection In Link Between Permanent Hair Dye Use And Bladder Cancer Risk. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2002/04/020410075652.htm
University Of Southern California. "Genetic Connection In Link Between Permanent Hair Dye Use And Bladder Cancer Risk." ScienceDaily. www.sciencedaily.com/releases/2002/04/020410075652.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins