Featured Research

from universities, journals, and other organizations

High Levels Of Sex Hormones Doubles Risk For Breast Cancer In Postmenopausal Women

Date:
April 17, 2002
Source:
Fox Chase Cancer Center
Summary:
Postmenopausal women with relatively high serum concentrations of estrogen and testosterone have about twice the risk of developing breast cancer as women with relatively low serum concentrations of these sex hormones. That is the result of an international study published in the April 17, 2002 issue of the Journal of the National Cancer Institute.

PHILADELPHIA (April 16, 2002) -- Postmenopausal women with relatively high serum concentrations of estrogen and testosterone have about twice the risk of developing breast cancer as women with relatively low serum concentrations of these sex hormones. That is the result of an international study published in the April 17, 2002 issue of the Journal of the National Cancer Institute (volume 93, number 8).

The finding was reported by the Endogenous Hormones and Breast Cancer Collaborative Group. Joanne F. Dorgan, M.P.H, Ph.D., a member of the Population Science Division at Fox Chase Cancer Center is a lead investigator of one of nine cohorts included in the analysis.

"The overall results show that postmenopausal women with higher serum sex hormone levels including estradiol and testosterone were twice as likely to develop breast cancer," explained Dorgan.

"Associations between serum sex hormone levels and risk of developing breast cancer were not different in women who donated blood closer in time to diagnosis, indicating higher hormone levels in these women were not a preclinical finding."

In each of the nine cohorts included in the analysis, women who donated blood were followed for an average of 2 to 12 years. During that time 663 women developed breast cancer. Hormones in their blood were compared with the hormones of 1,765 women who were the same age when blood was donated as the women who developed breast cancer.

“The results are highly statistically significant and were not altered when we adjusted for established risk factors for breast cancer,” added Dorgan. Some of the known risk factors for breast cancer are never having been pregnant, early menarche, and in postmenopausal women, late menopause, use of hormone replacement therapy, and being overweight."

“More analyses are planned to increase our understanding of what factors influence a woman's risk of breast cancer," Dorgan stated. "The ultimate goal is to identify ways to prevent breast cancer, which affects 193,700 women in the United States annually. ” The Endogenous Hormones and Breast Cancer Collaborative Group is international consortium that includes epidemiologists from the United States, England, Italy, and Japan. The group conducts research on the relationship of endogenous hormones to breast cancer development. Each of the nine cohorts in which the association of sex hormones with breast cancer has been prospectively evaluated is represented in this study. For the current analysis, researchers from each of the nine cohorts pooled their data so they could obtain more precise estimates of the risk of developing breast cancer associated with elevated estrogen and androgen levels. The larger sample size achieved by pooling the data also allows for analyses of subsets of interest.

The nine cohorts and the principal investigators who make up the Endogenous Hormones and Breast Cancer Collaborative Group include: the Columbia, MO. cohort (JF Dorgan), the Guernsey, UK cohort (TJ Key); Nurses' Health Study cohort (SE Hankinson), New York University Women's Health Study cohort (PG Toniolo), the ORDET, Italy cohort (F Berrino), the Rancho Bernardo cohort (E Barrett-Connor), the RERF, Japan cohort (M Kabuto), the SOF cohort (JA Cauley), and the Washington County, MD cohort (KJ Helzlsouer). Fox Chase Cancer Center, one of the nation’s first comprehensive cancer centers designated by the National Cancer Institute in 1974, conducts basic and clinical research; programs of prevention, detection and treatment of cancer; and community outreach. For more information about Fox Chase activities, visit the Center’s web site at http://www.fccc.edu or call 1-888-FOX CHASE.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "High Levels Of Sex Hormones Doubles Risk For Breast Cancer In Postmenopausal Women." ScienceDaily. ScienceDaily, 17 April 2002. <www.sciencedaily.com/releases/2002/04/020417070120.htm>.
Fox Chase Cancer Center. (2002, April 17). High Levels Of Sex Hormones Doubles Risk For Breast Cancer In Postmenopausal Women. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2002/04/020417070120.htm
Fox Chase Cancer Center. "High Levels Of Sex Hormones Doubles Risk For Breast Cancer In Postmenopausal Women." ScienceDaily. www.sciencedaily.com/releases/2002/04/020417070120.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins