Featured Research

from universities, journals, and other organizations

Human Papilloma Virus Test Increases Cancer Detection Rate, Study Finds

Date:
May 8, 2002
Source:
Georgetown University Medical Center
Summary:
Adding a simple, highly sensitive test for the human papilloma virus (HPV) to the administration of the routine Pap test significantly increases the detection rate for cervical cancer and lowers death rates from this invasive disease, researchers at Georgetown University Medical Center’s Lombardi Cancer Center have found. Their findings are published in the May 8 Journal of the American Medical Association.

Adding a simple, highly sensitive test for the human papilloma virus (HPV) to the administration of the routine Pap test significantly increases the detection rate for cervical cancer and lowers death rates from this invasive disease, researchers at Georgetown University Medical Center’s Lombardi Cancer Center have found. Their findings are published in the May 8 Journal of the American Medical Association.

Using a computer model to simulate a large population of women 20 and older, the researchers evaluated the effectiveness of screening women with a combination of screening strategies—with both the HPV and Pap tests, with the Pap smear alone, or with only the HPV test. They found that using both screening tests, as opposed to the Pap test alone, would detect an additional 225 cancers per 100,000 women. The detection of these cancers would decrease cervical cancer mortality by 59%. HPV is a sexually transmitted virus and one of the leading causes of cervical cancer.

Current clinical guidelines recommend that women receive the Pap test alone every one to three years. Guidelines recently published by the American Society for Colposcopy and Cervical Pathology recommend HPV testing for women whose Pap test results are abnormal but inconclusive. The Georgetown study goes a step further by suggesting that adding the HPV test to biennial Pap tests at the outset is a cost-effective and potentially life-saving alternative for routine screening.

The incidence and death rates from cervical cancer have declined substantially in the United States over the last 50 years due to widespread Pap smear screening programs, but prior studies have shown that as many as half of all precancers or cancers could be missed by the Pap test. The HPV test detects the presence of the virus, whereas the Pap test (named for test designer George Papanicolaou) detects early abnormal cell changes that could lead to cervical cancer.

“For years, Pap smears have been the standard of care in screening for cervical cancer,” said Jeanne Mandelblatt, MD, professor of oncology and lead author of this paper. “What we’ve found is that adding an HPV test upfront not only increases cancer detection rate, it is also cost-effective to do so.”

However, the authors noted, “regardless of the method, the greatest health gains from screening will depend on reaching all women and ensuring access to diagnosis after an abnormal screening result.”

###Funding for this study was provided by the National Institute on Aging and the U.S. Army.

Georgetown University Medical Center includes the nationally ranked School of Nursing & Health Studies, the School of Medicine, the Lombardi Cancer Center and a $120 million biomedical research enterprise. The Lombardi Cancer Center is one of only 40 National Cancer Institute-designated comprehensive cancer centers in the nation, and the only one in the Washington DC area.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Human Papilloma Virus Test Increases Cancer Detection Rate, Study Finds." ScienceDaily. ScienceDaily, 8 May 2002. <www.sciencedaily.com/releases/2002/05/020508074145.htm>.
Georgetown University Medical Center. (2002, May 8). Human Papilloma Virus Test Increases Cancer Detection Rate, Study Finds. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2002/05/020508074145.htm
Georgetown University Medical Center. "Human Papilloma Virus Test Increases Cancer Detection Rate, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2002/05/020508074145.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins