Featured Research

from universities, journals, and other organizations

University Of Central Florida Researchers Find That Nanomaterials Developed For Industry Triple Or Quadruple Life Of Brain Cells

Date:
August 14, 2003
Source:
University Of Central Florida
Summary:
A molecular biologist and a nanoscientist at the University of Central Florida have found that nanomaterials developed for industry have an unexpected and potentially revolutionary side effect: They can triple or quadruple the life of brain cells.

ORLANDO, Aug. 13, 2003 -- A molecular biologist and a nanoscientist at the University of Central Florida have found that nanomaterials developed for industry have an unexpected and potentially revolutionary side effect: They can triple or quadruple the life of brain cells.

The result is people could live longer and with fewer age-related health problems.

Beverly Rzigalinski, assistant professor in the Department of Molecular Biology and Microbiology and at the Biomolecular Sciences Center, and Sudipta Seal, associate engineering professor at the Advanced Materials Processing and Analysis Center and the Department of Mechanical, Materials and Aerospace Engineering, will receive $1.4 million from the National Institutes of Health, National Institute on Aging to study the reasons behind the reaction and possible future applications.

Rzigalinski has spent the bulk of her career on NIH-funded research from the National Institute of Neurological Disorders and Stroke studying how brain cells "talk" to each other, most recently focusing on microglia -- a specialized cell that responds to brain injury and initiates the response to either repair or destroy the damaged neuron. Seal creates nanostructure materials and recently developed a process for engineering particles on a nanoscale -- so they might have more efficient industrial applications.

Because of the current flurry of publicity that anti-oxidants have received for their potential anti-aging properties, Rzigalinski decided to explore introducing the miniaturized particles to the brain cells of rats.

"In culture, rat brain cells usually live about three weeks," Rzigalinski said. "The cells exposed to the engineered nanoparticles lived three to four times longer."

To confirm the results, Rzigalinski, the grant's principal investigator, repeated the process multiple times and found that cells exposed to a single dose of engineered nano-oxide particles routinely outlived the untreated cells by three- to four-fold, with the longest living cell lasting 123 days.

Rzigalinski then explored the quality of the aged neurons and found they were signaling or "talking" to each other in the same manner as their youthful counterparts. "This shows there is a potential not just to extend the life span but to preserve function," she said.

Seal has worked on developing oxide particles for high temperature production since his undergraduate days in the late 1980s. In 2000, as he took over the coordination of UCF's nanotechnology initiative, he and a student developed ultrafine nano-sized powders and solutions. The particles, less than 10 nanometers (about 30 atoms) in size, not only offered a more efficient coating for use in machines but also opened the door for biological studies in collaboration with Rzigalinski.

When a university research administrator aware of the work of each scientist introduced the two, the possibilities immediately began forming. "This type of cross-disciplinary partnership is what we dream about," said Pallavoor Vaidyanathan, assistant vice president for research. It is also critical to forging frontiers in nanoscience.

Research in the medical profession suggests that a major component of aging is free radical damage to cells. Free radical scavengers, often taken in the form of vitamins, can counter the damage to a very limited degree. A regenerative nanoparticle, such as the one developed by Rzigalinski and Seal, offers promise of negating those problems and could be helpful in treatment of certain age-related disorders -- such as Alzheimer's disease -- as well as arthritis and other joint-related problems, Rzigalinski says.

Most recently, the Rzigalinski lab has found that the nanoparticles have potent anti-inflammatory properties. The investigators plan to explore the possibility of creating a coating from the particles that could be used for vascular and orthopedic implants, stents and other devices that are prone to inflammatory reactions.

Initial tests show that the nanoparticle anti-oxidants regenerate once they penetrate the cell -- meaning one dose could conceivably continue its therapeutic effects indefinitely.

Rzigalinski introduced the collaboration to her colleagues at the NATURE biotechnology symposium in Miami earlier this year. She has also submitted an abstract on the project to the National and International Neurotrauma Symposium, and Society for Neuroscience.

Nanotechnology is considered the new frontier of science, and it could revolutionize modern medicine in the future. The potential for creating new materials at a size capable of being absorbed by human cells calls for a new type of scientist -- one who can collaborate across seemingly unrelated disciplines. Combining the fields of biomolecular science with engineering offers a significant step in that direction.

Pappachan Kolattukudy, director of UCF's Biomolecular Science Center and a consultant on the project, said the collaboration is part of a strategy that UCF is going to be using increasingly in building its presence in the biomolecular sciences.

"We are concentrating on building interfaces between areas in which we have strengths," Kolattukudy said.

Vimal Desai, director of AMPAC, said that nanomaterials are currently considered highly strategic for important applications ranging from homeland security to just plain good health.

"It is so good to be able to build bridges for an interdisciplinary effort through competent and dynamic researchers at UCF," Desai said.


Story Source:

The above story is based on materials provided by University Of Central Florida. Note: Materials may be edited for content and length.


Cite This Page:

University Of Central Florida. "University Of Central Florida Researchers Find That Nanomaterials Developed For Industry Triple Or Quadruple Life Of Brain Cells." ScienceDaily. ScienceDaily, 14 August 2003. <www.sciencedaily.com/releases/2003/08/030814072145.htm>.
University Of Central Florida. (2003, August 14). University Of Central Florida Researchers Find That Nanomaterials Developed For Industry Triple Or Quadruple Life Of Brain Cells. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2003/08/030814072145.htm
University Of Central Florida. "University Of Central Florida Researchers Find That Nanomaterials Developed For Industry Triple Or Quadruple Life Of Brain Cells." ScienceDaily. www.sciencedaily.com/releases/2003/08/030814072145.htm (accessed August 30, 2014).

Share This




More Matter & Energy News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Australian Airlines Relax Phone Ban Too

Australian Airlines Relax Phone Ban Too

Reuters - Business Video Online (Aug. 26, 2014) Qantas and Virgin say passengers can use their smartphones and tablets throughout flights after a regulator relaxed a ban on electronic devices during take-off and landing. As Hayley Platt reports the move comes as the two domestic rivals are expected to post annual net losses later this week. Video provided by Reuters
Powered by NewsLook.com
Hurricane Marie Brings Big Waves to California Coast

Hurricane Marie Brings Big Waves to California Coast

Reuters - US Online Video (Aug. 26, 2014) Huge waves generated by Hurricane Marie hit the Southern California coast. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Chinese Researchers Might Be Creating Supersonic Submarine

Chinese Researchers Might Be Creating Supersonic Submarine

Newsy (Aug. 26, 2014) Chinese researchers have expanded on Cold War-era tech and are closer to building a submarine that could reach the speed of sound. Video provided by Newsy
Powered by NewsLook.com
Breakingviews: India Coal Strained by Supreme Court Ruling

Breakingviews: India Coal Strained by Supreme Court Ruling

Reuters - Business Video Online (Aug. 26, 2014) An acute coal shortage is likely to be aggravated as India's supreme court declared government coal allocations illegal, says Breakingviews' Peter Thal Larsen. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins