Featured Research

from universities, journals, and other organizations

Research Indicates Why Radiation Therapy Reduces Bone Cancer Pain

Date:
February 2, 2004
Source:
University Of Minnesota
Summary:
Using an experimental radiation model, University of Minnesota Cancer Center researchers and colleagues have determined that radiation treatment may relieve pain by reducing bone tumor size and decreasing progression of cancer-induced bone destruction.

Although physicians administer radiation therapy to relieve bone cancer pain in more than 100,000 patients each year in the United States, little is known about why the treatment works. Using an experimental radiation model, University of Minnesota Cancer Center researchers and colleagues have determined that radiation treatment may relieve pain by reducing bone tumor size and decreasing progression of cancer-induced bone destruction. The findings appear in February issue of the journal Radiation Research.

"Perhaps the greatest obstacle to improving pain relief following radiation of bone cancer is our limited knowledge regarding mechanisms responsible for decreasing the pain," said lead investigator Denis Clohisy, M.D., professor of orthopedic surgery in the Medical School and Cancer Center member. "Future use of the experimental system described in this research should help accelerate the pace of discovery around these mechanisms and help efforts to reduce the burden of pain suffered by bone cancer patients."

Researchers in this investigation created an experimental model that limited radiation to the site of cancer in mice and then used an established bone pain model, imaging techniques, and histologic evaluations to understand the effects of radiation.

The research demonstrated that a localized, single radiation dose decreased painful behavior and increased limb use, which was associated with a decrease in bone destruction and tumor burden. Treated mice demonstrated greater pain relief and had significantly less bone destruction and tumor burden than untreated mice. Recent studies have demonstrated that tumor burden and bone destruction each correlate with behavioral and neurochemical measures of pain.

Co-authors of this study are Bruce J. Gerbi, Ph.D., Parham Alaei, Ph.D., Patrick W. Mantyh, J.D., Ph.D., Michael Goblirsch, B.A., Wendy E. Mathews, B.S., and Christine Lynch, B.S.

###

The Cancer Center at the University of Minnesota is a National Cancer Institute-designated Comprehensive Cancer Center. Awarded more than $80 million in peer-reviewed grants during fiscal year 2003, the Cancer Center conducts cancer research that advances knowledge and enhances care. The center also engages community outreach and public education efforts addressing cancer. To learn more about cancer, visit the University of Minnesota Cancer Center Web site at http://www.cancer.umn.edu. For cancer questions, call the Cancer Center information line at 1-888-CANCER MN (1-888-226-2376) or 612-624-2620 in the metro area.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Research Indicates Why Radiation Therapy Reduces Bone Cancer Pain." ScienceDaily. ScienceDaily, 2 February 2004. <www.sciencedaily.com/releases/2004/02/040202064127.htm>.
University Of Minnesota. (2004, February 2). Research Indicates Why Radiation Therapy Reduces Bone Cancer Pain. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2004/02/040202064127.htm
University Of Minnesota. "Research Indicates Why Radiation Therapy Reduces Bone Cancer Pain." ScienceDaily. www.sciencedaily.com/releases/2004/02/040202064127.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins