Apr. 9, 2004 As attention deficit hyperactivity disorder (ADHD) affects around 1 in every 25 school-aged children, managing this condition is of huge social importance. An article published in BMC Psychiatry this week shows that zinc supplements could increase the effectiveness of stimulants used to treat children with the disease.
The effects of ADHD on individual children differ, but symptoms include inattention, hyperactivity and impulsiveness. Stimulants are the most common treatment prescribed, but recent findings that vitamin and mineral deficiencies correlate with ADHD suggest that dietary supplements could also play a role in disease management.
Researchers from Iran carried out a controlled trial to assess the benefits of prescribing supplementary zinc alongside the more conventional methylphenidate treatment. They found that children taking additional zinc sulphate on a daily basis improved faster than those taking a placebo.
"The efficacy of zinc sulphate to increase the rate of improvement in children, seems to support the role of zinc deficiency in the pathogenesis of ADHD," say the authors.
The study comprised 44 children who were diagnosed as suffering from ADHD at Roozbeh Psychiatric Hospital, Tehran. Prior to the trial none of these patients had taken any medication for their condition.
For the six weeks of the trial, half the children took zinc sulphate (55mg/day) in addition to the conventional treatment; the other half took a placebo. A child psychiatrist assessed the children's condition fortnightly.
The behaviour of both groups of children improved over the course of the trial, but the children taking the zinc supplements showed a more marked improvement in their condition after six weeks, compared with those taking the placebo.
Although the children taking zinc sulphate were three times more likely to report that they were suffering from nausea, the frequency of other side effects did not differ between the two study groups. However, almost all of the children taking supplementary zinc complained about the metallic taste of the tablets.
Zinc supplements may exert their positive effects by helping to regulate the function of the neurotransmitter dopamine. Dopamine signalling, which has been implicated in causing symptoms of ADHD, is believed to play an important role in the feelings of pleasure and reward.
The authors acknowledge that their study is only small. They suggest that further research in this area is needed to confirm the positive effects of zinc supplements on children with ADHD.
This press release is based on the following article:
Zinc sulphate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial [ISRCTN64132371] Shahin Akhondzadeh, Mohammad-Reza Mohammadi, Mojgan Khademi BMC Psychiatry 2004, 4:8
Upon publication this article will be freely available according to BMC Psychiatry's Open Access policy at http://www.biomedcentral.com/1471-244X/4/8/
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