Featured Research

from universities, journals, and other organizations

Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite

Date:
November 4, 2004
Source:
Cell Press
Summary:
Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

Insect-borne parasites usually like to "stick" around inside their hosts while they mature and prepare to infect again.

Now, Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

PpGalec is the receptor protein that the parasite uses to bind to the fly's midgut and avoid being excreted at a particularly vulnerable stage of its development. "Identifying and targeting midgut molecules essential for parasite survival represents a novel strategy for development of transmission-blocking vaccines against vector-borne diseases," Valenzuela and colleagues conclude.

As Stephen Beverley and Deborah Dobson point out in an accompanying article, leishmaniasis is a common opportunistic infection in people with AIDS and has also been a recent concern for foreign soldiers serving in Iraq.

###

S. Kamhawi, M. Ramalho-Ortigao, V.M. Pham, S. Kumar, P.G. Lawyer, S.J. Turco, C. Barillas-Mury, D.L. Sacks, and J.G. Valenzuela: "A Role for Insect Galectins in Parasite Survival"

Publishing in Cell, Volume 119, Number 3, October 29, 2004 pages 329–341.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. ScienceDaily, 4 November 2004. <www.sciencedaily.com/releases/2004/10/041030213307.htm>.
Cell Press. (2004, November 4). Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2004/10/041030213307.htm
Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030213307.htm (accessed April 24, 2014).

Share This



More Science News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
Will New FCC Rules Trigger Death Of Net Neutrality?

Will New FCC Rules Trigger Death Of Net Neutrality?

Newsy (Apr. 24, 2014) The Federal Communications Commission will reportedly propose new rules for Net neutrality that could undermine the principles of a free and open Web. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins