Featured Research

from universities, journals, and other organizations

Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite

Date:
November 4, 2004
Source:
Cell Press
Summary:
Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

Insect-borne parasites usually like to "stick" around inside their hosts while they mature and prepare to infect again.

Now, Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

PpGalec is the receptor protein that the parasite uses to bind to the fly's midgut and avoid being excreted at a particularly vulnerable stage of its development. "Identifying and targeting midgut molecules essential for parasite survival represents a novel strategy for development of transmission-blocking vaccines against vector-borne diseases," Valenzuela and colleagues conclude.

As Stephen Beverley and Deborah Dobson point out in an accompanying article, leishmaniasis is a common opportunistic infection in people with AIDS and has also been a recent concern for foreign soldiers serving in Iraq.

###

S. Kamhawi, M. Ramalho-Ortigao, V.M. Pham, S. Kumar, P.G. Lawyer, S.J. Turco, C. Barillas-Mury, D.L. Sacks, and J.G. Valenzuela: "A Role for Insect Galectins in Parasite Survival"

Publishing in Cell, Volume 119, Number 3, October 29, 2004 pages 329–341.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. ScienceDaily, 4 November 2004. <www.sciencedaily.com/releases/2004/10/041030213307.htm>.
Cell Press. (2004, November 4). Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2004/10/041030213307.htm
Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030213307.htm (accessed September 21, 2014).

Share This



More Science News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Will Climate Rallies Spur Change?

Will Climate Rallies Spur Change?

Newsy (Sep. 21, 2014) — Organizers of the People's Climate March and other rallies taking place in 166 countries hope to move U.N. officials to action ahead of their summit. Video provided by Newsy
Powered by NewsLook.com
SpaceX Cargo Ship Blasts Off Toward Space Station

SpaceX Cargo Ship Blasts Off Toward Space Station

AFP (Sep. 21, 2014) — SpaceX's unmanned Dragon cargo ship blasts off toward the International Space Station, carrying a load of supplies and science experiments for the astronauts living there. Duration: 00:35 Video provided by AFP
Powered by NewsLook.com
NASA's MAVEN To Study Martian Atmosphere

NASA's MAVEN To Study Martian Atmosphere

Newsy (Sep. 21, 2014) — NASA's Maven will soon give information that could explain what happened to Mars' atmosphere. Video provided by Newsy
Powered by NewsLook.com
Thousands March in NYC Over Climate Change

Thousands March in NYC Over Climate Change

AP (Sep. 21, 2014) — Accompanied by drumbeats, wearing costumes and carrying signs, thousands of demonstrators filled the streets of Manhattan and other cities around the world on Sunday to urge policy makers to take action on climate change. (Sept. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins