Featured Research

from universities, journals, and other organizations

Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite

Date:
November 4, 2004
Source:
Cell Press
Summary:
Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

Insect-borne parasites usually like to "stick" around inside their hosts while they mature and prepare to infect again.

Related Articles


Now, Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

PpGalec is the receptor protein that the parasite uses to bind to the fly's midgut and avoid being excreted at a particularly vulnerable stage of its development. "Identifying and targeting midgut molecules essential for parasite survival represents a novel strategy for development of transmission-blocking vaccines against vector-borne diseases," Valenzuela and colleagues conclude.

As Stephen Beverley and Deborah Dobson point out in an accompanying article, leishmaniasis is a common opportunistic infection in people with AIDS and has also been a recent concern for foreign soldiers serving in Iraq.

###

S. Kamhawi, M. Ramalho-Ortigao, V.M. Pham, S. Kumar, P.G. Lawyer, S.J. Turco, C. Barillas-Mury, D.L. Sacks, and J.G. Valenzuela: "A Role for Insect Galectins in Parasite Survival"

Publishing in Cell, Volume 119, Number 3, October 29, 2004 pages 329–341.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. ScienceDaily, 4 November 2004. <www.sciencedaily.com/releases/2004/10/041030213307.htm>.
Cell Press. (2004, November 4). Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2004/10/041030213307.htm
Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030213307.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Science News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Amphipolis Tomb Architraves Reveal Faces

Amphipolis Tomb Architraves Reveal Faces

AFP (Nov. 22, 2014) Faces in an area of mosaics is the latest find by archaeologists at a recently discovered tomb dating back to fourth century BC and the time of Alexander the Great in Greece. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
European Parliament Might Call For Google's Break-Up

European Parliament Might Call For Google's Break-Up

Newsy (Nov. 22, 2014) This is the latest development in an antitrust investigation accusing Google of unfairly prioritizing own products and services in search results. Video provided by Newsy
Powered by NewsLook.com
Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins