Featured Research

from universities, journals, and other organizations

Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite

Date:
November 4, 2004
Source:
Cell Press
Summary:
Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

Insect-borne parasites usually like to "stick" around inside their hosts while they mature and prepare to infect again.

Now, Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

PpGalec is the receptor protein that the parasite uses to bind to the fly's midgut and avoid being excreted at a particularly vulnerable stage of its development. "Identifying and targeting midgut molecules essential for parasite survival represents a novel strategy for development of transmission-blocking vaccines against vector-borne diseases," Valenzuela and colleagues conclude.

As Stephen Beverley and Deborah Dobson point out in an accompanying article, leishmaniasis is a common opportunistic infection in people with AIDS and has also been a recent concern for foreign soldiers serving in Iraq.

###

S. Kamhawi, M. Ramalho-Ortigao, V.M. Pham, S. Kumar, P.G. Lawyer, S.J. Turco, C. Barillas-Mury, D.L. Sacks, and J.G. Valenzuela: "A Role for Insect Galectins in Parasite Survival"

Publishing in Cell, Volume 119, Number 3, October 29, 2004 pages 329–341.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. ScienceDaily, 4 November 2004. <www.sciencedaily.com/releases/2004/10/041030213307.htm>.
Cell Press. (2004, November 4). Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2004/10/041030213307.htm
Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030213307.htm (accessed April 20, 2014).

Share This



More Science News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

SpaceX's Dragon Spacecraft Captured by International Space Station

SpaceX's Dragon Spacecraft Captured by International Space Station

Reuters - US Online Video (Apr. 20, 2014) SpaceX's unmanned Dragon spacecraft makes a scheduled Easter Sunday rendezvous with the International Space Station. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Mich. Boy Unearths 10,000-Year-Old Mastodon Tooth

Mich. Boy Unearths 10,000-Year-Old Mastodon Tooth

Newsy (Apr. 20, 2014) A 9-year-old Michigan boy was exploring a creek when he came across a 10,000-year-old tooth from a prehistoric mastodon. Video provided by Newsy
Powered by NewsLook.com
Raw: Easter Morning Delivery for Space Station

Raw: Easter Morning Delivery for Space Station

AP (Apr. 20, 2014) Space station astronauts got a special Easter treat: a cargo ship full of supplies. The SpaceX company's cargo ship, Dragon, spent two days chasing the International Space Station following its launch from Cape Canaveral. (April 20) Video provided by AP
Powered by NewsLook.com
Nintendo Changed Gaming World, but Its Future Uncertain: Upstone

Nintendo Changed Gaming World, but Its Future Uncertain: Upstone

AFP (Apr. 19, 2014) The Nintendo Game Boy celebrates its 25th anniversary Monday and game expert Stephen Upstone says the console can be credited with creating a trend towards handheld gaming devices. Duration: 01:21 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins