Featured Research

from universities, journals, and other organizations

Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite

Date:
November 4, 2004
Source:
Cell Press
Summary:
Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

Insect-borne parasites usually like to "stick" around inside their hosts while they mature and prepare to infect again.

Now, Jesus Valenzuela and colleagues have identified the molecular receptor inside the midgut of the sand fly Phlebotomus papatasi that provides the "flypaper" for the parasite that causes the major form of leishmaniasis, a tropical disease with both mild and fatal forms.

PpGalec is the receptor protein that the parasite uses to bind to the fly's midgut and avoid being excreted at a particularly vulnerable stage of its development. "Identifying and targeting midgut molecules essential for parasite survival represents a novel strategy for development of transmission-blocking vaccines against vector-borne diseases," Valenzuela and colleagues conclude.

As Stephen Beverley and Deborah Dobson point out in an accompanying article, leishmaniasis is a common opportunistic infection in people with AIDS and has also been a recent concern for foreign soldiers serving in Iraq.

###

S. Kamhawi, M. Ramalho-Ortigao, V.M. Pham, S. Kumar, P.G. Lawyer, S.J. Turco, C. Barillas-Mury, D.L. Sacks, and J.G. Valenzuela: "A Role for Insect Galectins in Parasite Survival"

Publishing in Cell, Volume 119, Number 3, October 29, 2004 pages 329–341.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. ScienceDaily, 4 November 2004. <www.sciencedaily.com/releases/2004/10/041030213307.htm>.
Cell Press. (2004, November 4). Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2004/10/041030213307.htm
Cell Press. "Fly Gut's 'Sticky Spot' For Leishmaniasis Parasite." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030213307.htm (accessed September 3, 2014).

Share This



More Science News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
Japan Firm Showcases 'touchable' 3D Technology

Japan Firm Showcases 'touchable' 3D Technology

AFP (Sep. 2, 2014) Technology that generates touchable 3D imagery is unveiled in Japan, with its developers saying users could pull and push objects that are not really there. Duration: 01:07 Video provided by AFP
Powered by NewsLook.com
Why Is This Madden NFL Video Game Character 14 Inches Tall?

Why Is This Madden NFL Video Game Character 14 Inches Tall?

Newsy (Sep. 2, 2014) The newest Madden NFL video game has a few glitches, including a 14-inch player who's actually more than 6 feet tall in real life. Video provided by Newsy
Powered by NewsLook.com
Get A Mortgage, Receive A Cat — Only In Russia

Get A Mortgage, Receive A Cat — Only In Russia

Newsy (Sep. 2, 2014) The incentive is in keeping with a Russian superstition that it's good luck for a cat to be the first to cross the threshold of a new home. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins