Featured Research

from universities, journals, and other organizations

Special Imaging Study Shows Failing Hearts Are 'Energy Starved'

Date:
February 7, 2005
Source:
Johns Hopkins Medical Institutions
Summary:
Using magnetic resonance spectroscopy (MRS) for the first time to examine energy production biochemistry in a beating human heart, Johns Hopkins researchers have found substantial energy deficits in failing hearts.

Using magnetic resonance spectroscopy (MRS) for the first time to examine energy production biochemistry in a beating human heart, Johns Hopkins researchers have found substantial energy deficits in failing hearts.

The findings, published in the January 18 issue of the Proceedings of the National Academy of Sciences, confirm what many scientists have conjectured for years about heart failure, and suggest new treatments designed to reduce energy demand and/or augment energy transfer.

"The heart consumes more energy per gram than any other organ," notes Paul A. Bottomley, Ph.D., lead researcher and director of magnetic resonance research at the Johns Hopkins Department of Radiology. "While scientists have long known that nucleotide adenosine triphosphate (ATP) is the chemical that fuels heart contractions and that creatine kinase (CK) is the enzyme for one of the sources of ATP, we believe this is the first time someone has actually measured the flux of ATP produced by CK reaction in the beating human heart."

Specifically, Bottomley and a team of cardiologists and radiologists at Hopkins used MRS to provide direct molecular-level measurements of the CK supply in normal, stressed and failing human hearts. Other team members include Robert G. Weiss, M.D., and Gary Gerstenblith, M.D., both in the Cardiology Division of the Hopkins Department of Medicine.

For the study, the researchers used an MRI device that combines conventional magnetic resonance imaging with spectroscopy to provide not only images of the anatomy, but also direct measurements of the concentrations of various important biochemicals and their chemical reaction rates within the cells of various tissues. They first performed MRS on 14 healthy volunteers to measure cardiac CK flux at rest and with pharmaceutically induced stress to determine whether increased energy demand during stress increases the rate of ATP synthesis through CK.

Then, 17 patients with histories of heart failure were similarly tested to measure the CK flux. Results showed that CK flux in healthy hearts is adequate to supply energy to the heart over a fairly wide normal range of rest and stress conditions.

However, in patients with mild-to-moderate heart failure, there was a 50 percent reduction in the ATP energy supplied by the CK reaction. "The failing hearts have an energy supply deficit," says Bottomley. "The reduction is sufficiently large that the supply may be insufficient to match energy demands of the heart during stress or exercise, which is often when symptoms appear. Many factors may contribute to human heart failure, but a failure in the energy supply would certainly affect the heart's function if supply can't be met."


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Special Imaging Study Shows Failing Hearts Are 'Energy Starved'." ScienceDaily. ScienceDaily, 7 February 2005. <www.sciencedaily.com/releases/2005/02/050204212351.htm>.
Johns Hopkins Medical Institutions. (2005, February 7). Special Imaging Study Shows Failing Hearts Are 'Energy Starved'. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/02/050204212351.htm
Johns Hopkins Medical Institutions. "Special Imaging Study Shows Failing Hearts Are 'Energy Starved'." ScienceDaily. www.sciencedaily.com/releases/2005/02/050204212351.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins