Featured Research

from universities, journals, and other organizations

Special Imaging Study Shows Failing Hearts Are 'Energy Starved'

Date:
February 7, 2005
Source:
Johns Hopkins Medical Institutions
Summary:
Using magnetic resonance spectroscopy (MRS) for the first time to examine energy production biochemistry in a beating human heart, Johns Hopkins researchers have found substantial energy deficits in failing hearts.

Using magnetic resonance spectroscopy (MRS) for the first time to examine energy production biochemistry in a beating human heart, Johns Hopkins researchers have found substantial energy deficits in failing hearts.

The findings, published in the January 18 issue of the Proceedings of the National Academy of Sciences, confirm what many scientists have conjectured for years about heart failure, and suggest new treatments designed to reduce energy demand and/or augment energy transfer.

"The heart consumes more energy per gram than any other organ," notes Paul A. Bottomley, Ph.D., lead researcher and director of magnetic resonance research at the Johns Hopkins Department of Radiology. "While scientists have long known that nucleotide adenosine triphosphate (ATP) is the chemical that fuels heart contractions and that creatine kinase (CK) is the enzyme for one of the sources of ATP, we believe this is the first time someone has actually measured the flux of ATP produced by CK reaction in the beating human heart."

Specifically, Bottomley and a team of cardiologists and radiologists at Hopkins used MRS to provide direct molecular-level measurements of the CK supply in normal, stressed and failing human hearts. Other team members include Robert G. Weiss, M.D., and Gary Gerstenblith, M.D., both in the Cardiology Division of the Hopkins Department of Medicine.

For the study, the researchers used an MRI device that combines conventional magnetic resonance imaging with spectroscopy to provide not only images of the anatomy, but also direct measurements of the concentrations of various important biochemicals and their chemical reaction rates within the cells of various tissues. They first performed MRS on 14 healthy volunteers to measure cardiac CK flux at rest and with pharmaceutically induced stress to determine whether increased energy demand during stress increases the rate of ATP synthesis through CK.

Then, 17 patients with histories of heart failure were similarly tested to measure the CK flux. Results showed that CK flux in healthy hearts is adequate to supply energy to the heart over a fairly wide normal range of rest and stress conditions.

However, in patients with mild-to-moderate heart failure, there was a 50 percent reduction in the ATP energy supplied by the CK reaction. "The failing hearts have an energy supply deficit," says Bottomley. "The reduction is sufficiently large that the supply may be insufficient to match energy demands of the heart during stress or exercise, which is often when symptoms appear. Many factors may contribute to human heart failure, but a failure in the energy supply would certainly affect the heart's function if supply can't be met."


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Special Imaging Study Shows Failing Hearts Are 'Energy Starved'." ScienceDaily. ScienceDaily, 7 February 2005. <www.sciencedaily.com/releases/2005/02/050204212351.htm>.
Johns Hopkins Medical Institutions. (2005, February 7). Special Imaging Study Shows Failing Hearts Are 'Energy Starved'. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2005/02/050204212351.htm
Johns Hopkins Medical Institutions. "Special Imaging Study Shows Failing Hearts Are 'Energy Starved'." ScienceDaily. www.sciencedaily.com/releases/2005/02/050204212351.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins