May 3, 2005 Pregnant women present during the September 11 World Trade Center collapse have passed on markers of Post Traumatic Stress Disorder (PTSD) to their unborn babies through transgenerational transmission. The findings strengthen the evidence for in utero or early life risk factors for the later development of adult mental or physical disorders. The study will be published online today in The Journal of Clinical Endocrinology & Metabolism, one of the four journals produced by The Endocrine Society.
Previous studies led researchers to believe that reduced cortisol levels observed in the adult children of Holocaust survivors could be attributed to mostly environmental factors, such as the stress of living with a parent who is depressed or anxious, or the experience of vicarious traumatization based on hearing stories of how parents suffered, rather than a 'transmitted' biological trait. "In the current study, reduced stress hormone levels were observed in infants, suggesting a larger role for very early environmental, genetic, or genetic-environmental interactions than previously thought," explains Rachel Yehuda, Ph.D., principal investigator of the study.
Scientists at Mount Sinai School of Medicine and the University of Edinburgh studied the relationship between maternal posttraumatic stress syndrome disorder (PTSD) symptoms and salivary cortisol levels in 38 women and their infants. Mothers who experienced symptoms of PTSD in response to 9/11 had lower cortisol levels compared to mothers who did not develop this condition. Moreover, approximately one year after birth, the babies of mothers who had developed PTSD symptoms had significantly lower cortisol levels compared to that in babies of mothers who developed only minimal symptoms. This decrease in cortisol levels among the infants was similar to their mothers' hormonal response to PTSD. Since lower cortisol levels in relation to maternal PTSD were most apparent in babies born to mothers who were in their third trimester on 9/11, the data implicate the possibility of in utero effects as contributors to a putative biological risk factor for PTSD.
"The findings suggest that mechanisms for transgenerational transmission of biologic effects of trauma may have to do with very early parent-child attachments," says Dr. Yehuda, "and possibly even in utero effects related to cortisol programming."
JCE&M is one of four journals published by The Endocrine Society. Founded in 1916, The Endocrine Society is the world's oldest, largest, and most active organization devoted to research on hormones, and the clinical practice of endocrinology. Endocrinologists are specially trained doctors who diagnose, treat and conduct basic and clinical research on complex hormonal disorders such as diabetes, thyroid disease, osteoporosis, obesity, hypertension, cholesterol and reproductive disorders. Today, The Endocrine Society's membership consists of over 12,000 scientists, physicians, educators, nurses and students, in more than 80 countries. Together, these members represent all basic, applied, and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society, and the field of endocrinology, visit the Society's web site at www.endo-society.org
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