Featured Research

from universities, journals, and other organizations

Link Suggested Between Regions On Two Chromosomes And Bipolar Disorder

Date:
September 16, 2005
Source:
Harvard School of Public Health
Summary:
An international team of 53 researchers led by HSPH scientists has offered the most convincing evidence so far linking bipolar disorder, also known as manic depression, to two chromosomal regions in the human genome.

Related Articles


"Even though bipolar disorder affects millions of peoplearound the world-sometimes throughout their lifetimes-what weunderstand to be biologically relevant at the genetic level is notterribly characterized," said Matthew McQueen, lead author andpostdoctoral fellow in the Department of Epidemiology at the HarvardSchool of Public Health (HSPH). "This research can help focus the fieldto identify viable candidate genes."

The study will appear in theOctober issue of the American Journal of Human Genetics and isavailable now in the journal's electronic edition online at http://www.journals.uchicago.edu/AJHG/journal/contents/v77n4.html.

Morethan two million American adults have bipolar disorder, according tothe National Institute of Mental Health. Patients typically experiencedramatic mood swings from episodes of euphoria and high energy tofeelings of intense sadness, fatigue, and even suicide. Psychiatristshave identified two primary forms of the illness: bipolar I disorder,which is the classic form of recurring mania and depression, andbipolar II disorder, which has less severe episodes of mania. Treatmentoften includes medication.

The exact cause of the illness remainsunknown, but scientists suspect the involvement of several genes,coupled with environmental influences. A number of individual studieshave suggested genomic regions linked to bipolar disorder, but theirresults have been inconsistent and difficult to replicate, leaving thefield "standing at a crossroads, wondering in which direction to gonext," said McQueen.

To establish more definitive research,McQueen and his colleagues did something unusual. They secured and thencombined original genome scan data from 11 independent linkage studies,instead of relying on the more common approach of using summary datafrom such studies.

"The use of original data made a significantdifference in our ability to control for variation in several factorsamong the different data sets and to make the overall analysis muchmore consistent and powerful," said Nan Laird, HSPH Professor ofBiostatistics and senior author on the paper.

The resultinganalysis involved 1,067 families and 5,179 individuals from NorthAmerica, Italy, Germany, Portugal, the UK, Ireland, and Israel, who hadprovided blood samples and family medical histories. The research teamcombined the data into a single genome scan and found strong geneticsignals on chromosomes 6 and 8. The team now hopes to narrow the searchto find associations between specific genes and the mental illness.

Theanalysis was funded through the Study of Genetic Determinants ofBipolar Disorder Project at the National Institute of Mental Health.Other researchers on the analysis team represented MassachusettsGeneral Hospital, The Broad Institute, and the University of Pittsburgh.


Story Source:

The above story is based on materials provided by Harvard School of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Harvard School of Public Health. "Link Suggested Between Regions On Two Chromosomes And Bipolar Disorder." ScienceDaily. ScienceDaily, 16 September 2005. <www.sciencedaily.com/releases/2005/09/050916074815.htm>.
Harvard School of Public Health. (2005, September 16). Link Suggested Between Regions On Two Chromosomes And Bipolar Disorder. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2005/09/050916074815.htm
Harvard School of Public Health. "Link Suggested Between Regions On Two Chromosomes And Bipolar Disorder." ScienceDaily. www.sciencedaily.com/releases/2005/09/050916074815.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Judge OKs 65-Year Deal Over NFL Concussions

Judge OKs 65-Year Deal Over NFL Concussions

AP (Apr. 23, 2015) A judge has approved a potential $1 billion plan to resolve thousands of NFL concussion lawsuits filed by retired players. The NFL expects 6,000 of nearly 20,000 retired players to suffer from Alzheimer&apos;s disease or moderate dementia someday.(April 23) Video provided by AP
Powered by NewsLook.com
Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Newsy (Apr. 21, 2015) The use of complex tools has often been seen as a defining characteristic of humanity, but that notion is now in question. Video provided by Newsy
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins