Featured Research

from universities, journals, and other organizations

Kidney Transplant Patients Face Higher Skin Cancer Risk

Date:
September 29, 2005
Source:
Penn State
Summary:
People who receive a kidney transplant are nearly four times more likely than the general population to develop melanoma, a rare but deadly form of skin cancer, according to a study led by Christopher Hollenbeak, Ph.D., associate professor, Departments of Surgery and Health Evaluation Sciences, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center.

People who receive a kidney transplant are nearly four times morelikely than the general population to develop melanoma, a rare butdeadly form of skin cancer, according to a study led by ChristopherHollenbeak, Ph.D., associate professor, Departments of Surgery andHealth Evaluation Sciences, Penn State College of Medicine, Penn StateMilton S. Hershey Medical Center.

Related Articles


The study, to be published in CANCER, a peer-reviewed journal of theAmerican Cancer Society (Nov.1, 2005 issue), indicates increased riskfor patients who undergo kidney transplantation and who receivelong-term immuno-suppression. Furthermore, risk was highest overall inmen -increasing with age- but significantly lower in women andAfrican-Americans.

"The take-home message is that kidney transplantpatients-especially men-should have a regular, complete skinexamination as part of their routine health care," says Hollenbeak. "Inaddition, kidney transplant recipients should be educated aboutmelanoma and instructed on the importance of routine self-examination."

In the largest study to date, Hollenbeak and his colleaguescompared melanoma incidence rates from a registry of renal transplantpatients (89,786 patients) to melanoma incidence rates from generalpopulation data.

Of the various types of skin cancer, melanoma is one of thedeadliest, with a mortality rate up to 6 percent in some regions of theworld. The classic risk factors for melanoma are ultraviolet radiation,commonly caused by sunburns, a suppressed immune system, and familyhistory of abnormal moles. Studies demonstrate that the immune systemplays a critical role in monitoring the body for-and destroying-earlycancerous cells, including melanoma.

Prior studies have shown that patients takingimmunosuppressants after organ transplantation to be at higher risk forall cancers, but disagree that there is a link to higher risk of skincancer. The baseline low incidence of melanoma in the generalpopulation may contribute to conflicting data. Low incidence of diseasemeans that more people need to be studied to discern a true linkbetween immunosupressants and a greater risk for melanoma.

They found that renal transplant recipients are 3.6 times morelikely to develop melanoma than the general population. Though somemelanomas will develop immediately after transplant, risk continues toincrease approximately 5 percent per year from date of transplant. Menwho have had a kidney transplant are at greatest risk for melanoma, andrisk of melanoma increases rapidly with age. In contrast, while femalekidney transplant recipients are also at increased risk, their risk issignificantly lower than men and does not increase with age.

"Kidney transplant patients, who are receiving long-termimmunosuppression," conclude Hollenbeak and his colleagues, "have a3.6-fold increase in the incidence of melanoma when compared to thegeneral population," and should receive regular complete skinexaminations.

###

Article: "IncreasedIncidence of Melanoma in Renal Transplantation Recipients," ChristopherS. Hollenbeak, Ph.D., Departments of Surgery, Penn State College ofMedicine; Michael M. Todd, M.D., Skin Cancer Center of NorthernVirginia; Elizabeth M. Billingsley, M.D., Department of Dermatology,Penn State Milton S. Hershey Medical Center; Gregory Harper, M.D.,Ph.D., Penn State Cancer Institute, Lehigh Valley Hospital; Anne-MarieDyer, M.S. Department of Health Evaluation Sciences, Penn State Collegeof Medicine; Eugene J. Lengerich, V.M.D., M.S. Department of HealthEvaluation Sciences, Penn State Cancer Institute, Penn State College ofMedicine: CANCER; Published Online: Sept. 26, 2005 (DOI:10.1002/cncr.21404); Print issue: Nov. 1, 2005.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Cite This Page:

Penn State. "Kidney Transplant Patients Face Higher Skin Cancer Risk." ScienceDaily. ScienceDaily, 29 September 2005. <www.sciencedaily.com/releases/2005/09/050929082808.htm>.
Penn State. (2005, September 29). Kidney Transplant Patients Face Higher Skin Cancer Risk. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2005/09/050929082808.htm
Penn State. "Kidney Transplant Patients Face Higher Skin Cancer Risk." ScienceDaily. www.sciencedaily.com/releases/2005/09/050929082808.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins