Featured Research

from universities, journals, and other organizations

Penn Research Permits First-ever Visualization Of Psychological Stress In The Human Brain

Date:
November 23, 2005
Source:
University of Pennsylvania School of Medicine
Summary:
Using a novel application of an fMRI (functional magnetic resonance imaging) technique, researchers at the University of Pennsylvania School of Medicine have, for the first time, visualized the effects of everyday psychological stress in a healthy human brain. Their work, performed at Penn's Center for Functional Neuroimaging, provides a neuro-imaging marker of psychological stress -- which will pave the way for the development of improved strategies for preventing or correcting the long-term health consequences of chronic stress.

The background of this image shows the mean cerebral blood flow of all the subjects undergoing the stress tasks (here, mental arithmetic) acquired using the continuous arterial spin labeling (CASL) technique. The foreground shows the detected activation in the right prefrontal cortex -- an area long associated with anxiety and depression -- when the subjects are under stress.
Credit: Image Courtesy: Jiongjiong Wang, PhD, and John A. Detre, MD, University of Pennsylvania School of Medicine

Using a novel application of an fMRI (functional magnetic resonance imaging) technique, researchers at the University of Pennsylvania School of Medicine have, for the first time, visualized the effects of everyday psychological stress in a healthy human brain. Their work, performed at Penn's Center for Functional Neuroimaging, provides a neuro-imaging marker of psychological stress -- which will pave the way for the development of improved strategies for preventing or correcting the long-term health consequences of chronic stress. The researchers' study appears in the November 21 online edition of Proceedings of the National Academy of Sciences.

In the Penn study, researchers induced stress on healthy subjects by asking them to quickly tackle challenging mental exercises while being monitored for performance. During the fMRI scans, the researchers also recorded subjects' emotional responses -- such as stress, anxiety, and frustration -- and measured the corresponding changes in stress hormone and heart rate. Many subjects described themselves as being "flustered, distracted, rushed and upset" by the stress task.

The results showed increased cerebral blood-flow during the "stress test" in the right anterior portion of the brain (prefrontal cortex) -- an area long associated with anxiety and depression. More interestingly, the increased cerebral blood-flow persisted even when the testing was complete. These results suggest a strong link between psychological stress and negative emotions. On the other hand, the prefrontal cortex is also associated with the ability to perform executive functions -- such as working memory and goal-oriented behavior -- that permit humans to adapt to environmental challenges and threats. "The message from this study is that while stress may be useful in increasing focus, chronic stress could also be detrimental to mental health," concludes Jiongjiong Wang, PhD, Assistant Professor of Radiology and principal investigator of the study.

"How the brain reacts under psychological stress is an untouched subject for cognitive neuroscientists, but it is certainly a critical piece of the puzzle in understanding the health effects of stress," adds Wang. "Our findings should help significantly advance our understanding of this process."

To date, most fMRI studies have indirectly measured changes in cerebral blood-flow and metabolism induced by neural activation, using a technique that is sensitive to the oxygenation levels in blood. "The fMRI technique employed in our study -- arterial spin labeling -- can measure cerebral flood-flow directly," states John A. Detre, MD, Associate Professor of Neurology and Radiology, and senior author of the study. "This technique is very similar to PET (positron emission tomography) scanning, except that it's entirely non-invasive -- without the need for injections or radioactivity. In this elegant technique, water molecules in subjects' own blood are 'tagged' by the magnet and used as the natural contrast agent to measure cerebral blood-flow." Researchers at Penn's Center for Functional Neuroimaging have been at the forefront of the development of this technique, and its applications to imaging brain-function during cognitive and emotional processes.

###

The study was sponsored by grants from the National Science Foundation, the National Institutes of Health, and the U.S. Air Force. In addition to Drs. Wang and Detre, the team of investigators included Penn researchers Hengyi Rao, Gabriel S. Wetmore, Patricia M. Furlan, Marc Korczykowski, and David F. Dinges.

Editors' Notes: For more information about the Center for Functional Neuroimaging (CFN) at Penn, go to www.cfn.upenn.edu.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of Pennsylvania School of Medicine. "Penn Research Permits First-ever Visualization Of Psychological Stress In The Human Brain." ScienceDaily. ScienceDaily, 23 November 2005. <www.sciencedaily.com/releases/2005/11/051122210156.htm>.
University of Pennsylvania School of Medicine. (2005, November 23). Penn Research Permits First-ever Visualization Of Psychological Stress In The Human Brain. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2005/11/051122210156.htm
University of Pennsylvania School of Medicine. "Penn Research Permits First-ever Visualization Of Psychological Stress In The Human Brain." ScienceDaily. www.sciencedaily.com/releases/2005/11/051122210156.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins