Featured Research

from universities, journals, and other organizations

Rapidly Rising PSA Before Treatment Is Key Indicator Of Cancer Spread

Date:
November 9, 2006
Source:
Fox Chase Cancer Center
Summary:
Results of a new Fox Chase Cancer Center study show that men with a rapidly rising PSA level before treatment have a high probability of metastatic disease and should receive hormone therapy in addition to radiation.

Results of a new Fox Chase Cancer Center study show that men with a rapidly rising PSA level before treatment have a high probability of metastatic disease and should receive hormone therapy in addition to radiation. The findings were presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia.

The rate of a rise in PSA level, known as PSA velocity (PSAV), can be used to determine when prostate cancer spread may have already occurred, even in men with clinically localized disease. PSA, or prostate specific antigen, is measured by a blood test and used to determine if prostate cancer is present.

"We've known that men with a rapidly rising PSA are at greater risk of prostate cancer-related death and this study suggests that undetected distant metastasis present prior to radiation therapy may be the cause," explained Mark K. Buyyounouski, M.D., M.S., an attending physician in the radiation oncology department at Fox Chase and lead author of the study. The study looked at data collected between 1989 and 1999 for 671 men with clinically localized prostate cancer who received 3-D conformal radiation therapy.

Buyyounouski and others demonstrated that when the PSAV was greater than 2 ng/ml per year, the PSA was likely to continue rising at the same rate despite radiation therapy to the prostate. What's more, this group of men was found to have a greater likelihood of distant spread of prostate cancer and a greater risk of dying of the disease. This relationship was not seen for men with a slower PSAV of less than 2 ng/ml.

"This study suggests that an initially high PSAV often represents previously undetected metastatic disease exists at the time of diagnosis," said Buyyounouski. "This disease has the opportunity to progress if radiation therapy to the prostate and surrounding tissue is the only treatment," said Buyyounouski. "Therefore, it is recommended that the PSAV be used in addition to other high risk factors to determine if androgen deprivation therapy should be part of the treatment."

Androgen deprivation therapy, or hormone therapy, has been shown to improve survival when used in conjunction with radiation therapy for men at high risk of undetected spread of prostate cancer.

Buyyounouski concluded that requiring a PSAV of less than 2 ng/ml will be important for selecting patients who are most likely to benefit from radiation therapy alone. This has important implications for studies designed to compare various radiation regimens such as hypofractionation.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Rapidly Rising PSA Before Treatment Is Key Indicator Of Cancer Spread." ScienceDaily. ScienceDaily, 9 November 2006. <www.sciencedaily.com/releases/2006/11/061108154857.htm>.
Fox Chase Cancer Center. (2006, November 9). Rapidly Rising PSA Before Treatment Is Key Indicator Of Cancer Spread. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2006/11/061108154857.htm
Fox Chase Cancer Center. "Rapidly Rising PSA Before Treatment Is Key Indicator Of Cancer Spread." ScienceDaily. www.sciencedaily.com/releases/2006/11/061108154857.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins