Featured Research

from universities, journals, and other organizations

Stem Cells Decrease Ischemic Injury And Restore Brain Function

Date:
April 18, 2007
Source:
Public Library of Science
Summary:
Stroke is the first cause of permanent invalidity and the third cause of death in industrialized countries. Despite the recent advancements in the management of ischemic patients (early diagnosis, thrombolysis, stroke units and rehabilitation centers), stroke still represents a major and unresolved medical issue.

Stroke is the first cause of permanent invalidity and the third cause of death in industrialized countries.

Despite the recent advancements in the management of ischemic patients (early diagnosis, thrombolysis, stroke units and rehabilitation centers), stroke still represents a major and unresolved medical issue.

"Stroke causes the death of many nervous cells that, in theory, could be substituted by stem cells. A few studies have shown that these cells can be effective, although various issues about their use and the mechanisms of their protective action remained unsolved," says Maria Grazia De Simoni.

"Our research has underlined a possible mechanism of action. Once introduced in the area of the brain hit by a stroke, stem cells induce the development of a protective effect in this same area," explains De Simoni. "Therefore, it is not necessary, as proposed in past studies, for stem cells to turn into neurons in order to protect the brain from ischemic injury and restore brain functions. Their presence in brain tissue is sufficient to induce a protective reaction."

Various cells are involved in this reaction, among which the microglia, which has always been thought to have a toxic and inflammatory role. "Instead, we suggest that the microglia also has a protective function," says De Simoni. "Moreover our research shows that these cells survive in brain tissue only for a few days and then they are eliminated. This is very important given the possibility that stem cells may turn into cancer cells."

This study was carried out by a group of researchers coordinated by Dr. Maria Grazia De Simoni of the Mario Negri Institute in Milan, Italy in cooperation with the Istituto Neurologico Besta (Milan) and the University of Lausanne.

Citation: Capone C, Frigerio S, Fumagalli S, Gelati M, Principato M-C, et al (2007) Neurosphere-Derived Cells Exert a Neuroprotective Action by Changing the Ischemic Microenvironment. PLoS ONE 2(4): e373. doi:10.1371/journal.pone.0000373 http://dx.doi.org/10.1371/journal.pone.0000373


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Stem Cells Decrease Ischemic Injury And Restore Brain Function." ScienceDaily. ScienceDaily, 18 April 2007. <www.sciencedaily.com/releases/2007/04/070417203146.htm>.
Public Library of Science. (2007, April 18). Stem Cells Decrease Ischemic Injury And Restore Brain Function. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2007/04/070417203146.htm
Public Library of Science. "Stem Cells Decrease Ischemic Injury And Restore Brain Function." ScienceDaily. www.sciencedaily.com/releases/2007/04/070417203146.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins