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New Statistical Technique Shows More Informative Picture Of Cancer Survival

Date:
January 8, 2008
Source:
Journal of the National Cancer Institute
Summary:
Researchers have developed a new method for presenting clinical trial survival data that includes data from all trial participants unlike the standard method, according to a commentary published in the Journal of the National Cancer Institute.

Researchers have developed a new method for presenting clinical trial survival data that includes data from all trial participants unlike the standard method, according to a commentary published online January 8 in the Journal of the National Cancer Institute.

In clinical studies, "time-to-event" data represents the time from the start of a study to an event, such as disease recurrence or death. But often many participants in a study do not experience an event before the study is over, so their survival time is not known. To overcome this data gap, the standard statistical method for presenting time-to-event results, known as the Kaplan-Meier survival curve, involves plotting the proportion of individuals surviving without an event over the period of the study. Using this method, researchers get an estimate of the median survival times. However, these plots also tend to make differences in survival between groups visually appear larger than they actually are.

To address this problem, Patrick Royston, D.Sc., of the Medical Research Council Clinical Trials Unit in London and colleagues developed a new method for plotting survival as a bar graph and tested it on data from a kidney cancer trial. In cases where a participant had not experienced an event, the researchers estimated that person's survival by using their prognosis and length of time in the trial.

Their plots show considerable overlap in survival times between treatment and control groups in the kidney cancer trial, whereas the Kaplan--Meier plots of the same data showed a distinct separation between the two groups. The authors argue that the new method gives a more realistic representation of what are usually small differences between groups.

"The method is surprisingly informative and, we hope, will help physicians and patients to understand more fully the results of clinical trials and the implications of prognostic assessments," the authors write.

In an accompanying editorial, Janet Wittes, Ph.D., of Statistics Collaborative in Washington, D.C., discusses the challenges in interpreting time-to-events graphs, how this new method addresses these problems, and under what circumstances this method should be used.

"Those of us who work with time-to-event data should now attempt to extend their method to...settings other than survival," Wittes writes.

Citations:

Article: Royston P, Parmar MKB, Altman DG. Visualizing Length of Survival in Time-to-Event Studies: A Complement to Kaplan -- Meier Plots. J Natl Cancer Inst 2008; 100:92-97

Times to Event: Wittes J. Why Are They Hard to Visualize" J Natl Cancer Inst 2008; 100:80-81


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "New Statistical Technique Shows More Informative Picture Of Cancer Survival." ScienceDaily. ScienceDaily, 8 January 2008. <www.sciencedaily.com/releases/2008/01/080108183112.htm>.
Journal of the National Cancer Institute. (2008, January 8). New Statistical Technique Shows More Informative Picture Of Cancer Survival. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/01/080108183112.htm
Journal of the National Cancer Institute. "New Statistical Technique Shows More Informative Picture Of Cancer Survival." ScienceDaily. www.sciencedaily.com/releases/2008/01/080108183112.htm (accessed October 1, 2014).

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