Featured Research

from universities, journals, and other organizations

Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests

Date:
February 15, 2008
Source:
University of Kentucky
Summary:
Researchers have discovered a possible added benefit of a novel new drug that lowers blood pressure.They found in animal studies that aliskiren not only lowered blood pressure but also significantly reduced artery-clogging lesions that are the leading cause of heart attack and stroke, the top cause of death worldwide.

University of Kentucky researchers have discovered a possible added benefit of a novel new drug that lowers blood pressure.

Dr. Lisa Cassis and Dr. Alan Daugherty found in animal studies* that aliskiren not only lowered blood pressure but also significantly reduced artery-clogging lesions that are the leading cause of heart attack and stroke, the top cause of death worldwide.

"In my many years of atherosclerosis research, this is one of the most striking effects I have seen on preventing the disease under experimental conditions," Daugherty said. "This contributes to our knowledge of the underlying disease that causes heart attack and stroke."

Aliskiren, marketed under the brand name Tekturna by pharmaceutical manufacturer Novartis, is the first new class of blood pressure medication approved by the FDA in more than a decade. Approved a year ago, it acts differently than any other medication currently on the market by inhibiting renin, an enzyme that is primarily produced in the kidneys. Renin is the first step in the synthesis of one of the most important molecules in blood pressure regulation.

Renin inhibition in mice with profound hypercholesterolemia was found to reduce the size of the artery hardening atherosclerotic plaques. Macrophages are cells that play a critical role in the development of atherosclerotic plaques and they were shown to produce proteins of the RAS system.

Further analysis indicated that when the bone marrow of mice with hypercholesterolemia was replaced with that of renin-deficient mice, a procedure that favors the production of renin-deficient macrophages, atherosclerotic plaque sizes were reduced.

The authors therefore concluded that macrophage-derived renin plays an important role in the development of atherosclerotic plaques.

"Our data shows that renin inhibition is an effective approach to both lowering blood pressure and directly inhibiting atherosclerosis. It will be interesting to determine whether this approach is more effective than the two other commonly used classes of drugs in the angiotensin system; ACE inhibitors and ARBs," Daugherty said.

*Cassis is director of the UK Graduate Center for Nutritional Sciences and Daugherty is director of the UK Cardiovascular Research Center.

Journal reference: Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. Journal of Clinical Investigation. February 14, 2008.

This research was funded in part by Novartis Institutes for Biomedical Research.


Story Source:

The above story is based on materials provided by University of Kentucky. Note: Materials may be edited for content and length.


Cite This Page:

University of Kentucky. "Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests." ScienceDaily. ScienceDaily, 15 February 2008. <www.sciencedaily.com/releases/2008/02/080214172715.htm>.
University of Kentucky. (2008, February 15). Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/02/080214172715.htm
University of Kentucky. "Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/02/080214172715.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins