Featured Research

from universities, journals, and other organizations

How Embryonic Livers Store Energy

Date:
February 27, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have uncovered how embryonic livers accumulate an important energy molecule even though they lacks the key enzyme responsible. In adults, the liver stores glycogen, a sugar polymer that provides a steady supply of blood glucose when needed (e.g. during fasting). Glycogen production is controlled by an enzyme called glucokinase (GK), and mutations resulting in too much or too little GK will lead to hypo- and hyper-glycemia, respectively.

Researchers have uncovered how embryonic livers accumulate an important energy molecule even though they lacks the key enzyme responsible.

In adults, the liver stores glycogen, a sugar polymer that provides a steady supply of blood glucose when needed (e.g. during fasting). Glycogen production is controlled by an enzyme called glucokinase (GK), and mutations resulting in too much or too little GK will lead to hypo- and hyper-glycemia, respectively.

One interesting biological mystery has been that embryonic livers can store plenty of glycogen, yet they don't produce any GK; the liver only starts making this enzyme after newborns drink their first carbohydrate-rich milk.

Joan Guinovart and colleagues found that embryonic mouse livers circumvent the lack of GK by greatly overproducing (~200 fold higher than adult liver) another enzyme known as hexokinase (HK). Such as high amount is necessary because while HK can make glycogen, it's really inefficient.

However, unlike GK, HK makes glycogen independent of blood-glucose levels, and the researchers confirmed this by fasting pregnant mice and observing the embryonic livers did not alter their glycogen accumulation.

Thus, by using HK, embryos safeguard their glycogen production from any changes in maternal diet to ensure abundant storage. This is critical since glycogen is a newborn's principal source of energy in the critical time between birth and first milk meal.

This research was recently published in the Journal Of Biological Chemistry.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "How Embryonic Livers Store Energy." ScienceDaily. ScienceDaily, 27 February 2008. <www.sciencedaily.com/releases/2008/02/080222143823.htm>.
American Society for Biochemistry and Molecular Biology. (2008, February 27). How Embryonic Livers Store Energy. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2008/02/080222143823.htm
American Society for Biochemistry and Molecular Biology. "How Embryonic Livers Store Energy." ScienceDaily. www.sciencedaily.com/releases/2008/02/080222143823.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins