Featured Research

from universities, journals, and other organizations

Genes Involved In Inflammation May Hold Clue To Age-related Macular Degeneration

Date:
March 4, 2008
Source:
University of Southampton
Summary:
Scientists have identified a new genetic risk factor for age-related macular degeneration (AMD), a major cause of untreatable blindness in elderly people in developed countries. AMD is a progressive disease affecting the retinal pigment in the macular region at the back of the eye. Building on previous research, which showed that genes that control inflammation were important for developing AMD, the researchers took DNA samples from 478 people with AMD and from 555 people with no signs of the disease. They then looked for evidence of variations in genes controlling the production and suppression of cytokines - powerful chemicals involved in inflammatory processes in the body.

A University of Southampton research team, led by Professor Andrew Lotery, has identified a new genetic risk factor for age-related macular degeneration (AMD), a major cause of untreatable blindness in elderly people in developed countries.

Related Articles


AMD is a progressive disease affecting the retinal pigment in the macular region at the back of the eye. Building on their previous research, which showed that genes that control inflammation were important for developing AMD, the researchers took DNA samples from 478 people with AMD and from 555 people with no signs of the disease. They then looked for evidence of variations in genes controlling the production and suppression of cytokines - powerful chemicals involved in inflammatory processes in the body.

Their work paid off when they identified that one of the genetic variants (251A/T), which is associated with a gene that boosts the production of interleukin 8 (known as IL-8), was significantly more common among the patients with AMD. This held true even after taking account of age, sex, weight, and smoking, which is a known risk factor for AMD.

'This is exciting research which helps us understand why people develop AMD,' says Professor Lotery. 'In the future we may be able to target patients with this genetic risk factor for specific anti-inflammatory treatments, maybe with something as simple as aspirin! This knowledge should allow us to get much better treatment results.'

Professor Lotery's research has been supported by the University of Southampton and the Gift of Sight appeal. He adds: 'I would like to thank everyone who has made a donation to this very worthwhile cause.'

If repeated in larger studies, Professor Lotery and his colleagues suggest that their findings might lead to the possibility of genetic screening for AMD and the development of biological agents to control it.

The paper 'Interleukin-B promoter polymorphism - 251A/T is a risk factor for age-related macular degeneration' is published online, ahead of print, by the British Journal of Ophthalmology. Br J Ophthalmol 2008; doi: 10.1136/bjo.2007.123190


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "Genes Involved In Inflammation May Hold Clue To Age-related Macular Degeneration." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/02/080229140218.htm>.
University of Southampton. (2008, March 4). Genes Involved In Inflammation May Hold Clue To Age-related Macular Degeneration. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/02/080229140218.htm
University of Southampton. "Genes Involved In Inflammation May Hold Clue To Age-related Macular Degeneration." ScienceDaily. www.sciencedaily.com/releases/2008/02/080229140218.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins