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Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's Disease

Date:
April 17, 2008
Source:
Wiley-Blackwell
Summary:
Existing evidence suggests that patients with Alzheimer's disease who have taken Huperzine A have improved general cognitive function, global clinical status, functional performance and reduced behavioral disturbance compared to patients taking placebos.

Existing evidence suggests that patients with Alzheimer's disease who have taken Huperzine A have improved general cognitive function, global clinical status, functional performance and reduced behavioural disturbance compared to patients taking placebos.

The research team came to this conclusion after studying data in six trials that involve a total of 454 patients.

Part of the damage involved in Alzheimer's disease is a loss of acetylcholine-containing neurons in the basal forebrain. This suggests that drugs that could inhibit cholinesterase, which breaks down acetylcholine, could increase the ability of remaining cholinergic neurons.

Scientists know that Huperzine A can block acetyl cholinesterase and that it can work both in the peripheral and central nervous systems. This makes it a promising agent for treating various forms of dementia including Alzheimer's disease.

"These findings are based on small number of trials, but the data indicate that it would be well worth setting up some more high quality assessments of this interesting drug," says Associate Professor Hongmei Wu, who led this research and works in the Department of Geriatrics at the West China Hospital of Sichuan University in Chengdu, Sichuan, China.

These findings are published in a Cochrane Review.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's Disease." ScienceDaily. ScienceDaily, 17 April 2008. <www.sciencedaily.com/releases/2008/04/080415194410.htm>.
Wiley-Blackwell. (2008, April 17). Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's Disease. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2008/04/080415194410.htm
Wiley-Blackwell. "Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2008/04/080415194410.htm (accessed April 24, 2014).

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