Featured Research

from universities, journals, and other organizations

DHEA Supplements Not Effective In Treating Cognitive Decline, Study Suggests

Date:
May 24, 2008
Source:
Wiley-Blackwell
Summary:
DHEA supplements are widely-available and touted as a preventive agent for many chronic diseases. A new study however, finds no evidence of a beneficial effect of DHEA supplements on cognitive function in healthy older adults.

DHEA supplements are widely-available and touted as a preventive agent for many chronic diseases. A new study published in Journal of the American Geriatrics Society finds no evidence of a beneficial effect of DHEA supplements on cognitive function in healthy older adults. The researchers believe that based on their study, DHEA supplements should not be recommended for enhancement of cognitive function or well-being in the general population.

DHEA is a naturally-occurring hormone in the human body that serves as a precursor to male and female sex steroid hormones (androgens and estrogens). Levels of DHEA peak between the ages of 20 and 30 and decline with age. By age 70, DHEA levels are only about 20 percent of what they were in young adulthood.

The research is the first long-term study (1-year in length) to examine the effects of supplementation in a healthy sample of older men and women. The study included 110 men and 115 women aged 55-85. They received either daily 50 mg doses of DHEA or a similar looking placebo pill for 1 year. Six cognitive function tests were given and measures of depression, perceptions of physical and emotional health, life satisfaction and sexual function were recorded at the beginning of the study and again after 12 months.

“We found that, although youthful levels of DHEA were restored in the group on treatment, the DHEA supplements had no benefits for cognitive function in these healthy older adults,” says Donna Kritz-Silverstein, lead author of the study. There were also no differences seen between those taking DHEA and those taking placebo in any of quality-of-life measures.

Previous clinical trials examining the effects of DHEA supplementation on cognitive function and quality-of-life have inconsistent results, with some showing positive effects and others showing no effect. However, these trials used small sample sizes, were of short duration (generally 2 weeks to 4 months) and did not include older men and women who were at an age when memory loss and cognitive impairment become more apparent. Also, unlike the participants in the majority of previous studies, the participants in this study were not selected for lower levels of DHEA, meaning the results reflect what would be found in the general population.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "DHEA Supplements Not Effective In Treating Cognitive Decline, Study Suggests." ScienceDaily. ScienceDaily, 24 May 2008. <www.sciencedaily.com/releases/2008/05/080521171805.htm>.
Wiley-Blackwell. (2008, May 24). DHEA Supplements Not Effective In Treating Cognitive Decline, Study Suggests. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2008/05/080521171805.htm
Wiley-Blackwell. "DHEA Supplements Not Effective In Treating Cognitive Decline, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/05/080521171805.htm (accessed August 28, 2014).

Share This




More Mind & Brain News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com
Brain Surgery in 3-D

Brain Surgery in 3-D

Ivanhoe (Aug. 27, 2014) Neurosurgeons now have a new approach to brain surgery using the same 3D glasses you’d put on at an IMAX movie theater. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins