Featured Research

from universities, journals, and other organizations

The Good And The Bad Of A Potential Alzheimer's Target

Date:
June 29, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Research in fruit flies has shown that enhancing the production of a protein called neprilysin can reduce the formation of plaques and neuron death associated with Alzheimer's, at the expense of reducing the flies' lifespan.

Research in fruit flies has shown that enhancing the production of a protein called neprilysin can reduce the formation of plaques and neuron death associated with Alzheimer's, at the expense of reducing the flies' lifespan.

Related Articles


The buildup of amyloid-beta protein plaques within the brain is a major hallmark of Alzheimer's, and one that is believed to contribute to disease progression. Normally, special enzymes chew up and clear these plaques, and deficiencies in these enzymes are one potential disease cause.

In fact, one major amyloid degrader called neprilysin (NEP) decreases naturally with age and may be the reason the elderly are more at risk for Alzheimer's. Enhancing NEP production might therefore be an attractive therapy, and studies in mice have suggested it has potential. However, no studies have really looked into possible adverse effects of over-activating NEP (after all, nature probably turns it off for a reason).

In this study, research groups led by Koichi Iijima and Kanae Iijima-Ando did just that, using transgenic fruit flies expressing human NEP and/or amlyoid-beta protein. On the positive side, NEP expression did reduce plaque deposits and neuron damage in the flies as expected; on the other hand, NEP also reduced the activity of important neural proteins called CREB proteins and shortened the average lifespan of the flies (normal flies live about 60 days) by about 10 days (although NEP-flies did live longer than those only expressing amyloid protein).

This study illustrates the care that must be taken when considering Alzheimer's treatments, and that it's critical to better understand normal aging when dealing with Alzheimer's or other age-related conditions.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Overexpression of Neprilysin Reduces Alzheimer's Amyloid-Č 42 (AČ42)-Induced Neuron Loss and Intraneuronal AČ42 Deposits, but Causes a Reduction in CREB-Mediated Transcription, Age-Dependent Axon Pathology and Premature Death in DROSOPHILA. JBC, (online June 27, 2008)

Cite This Page:

American Society for Biochemistry and Molecular Biology. "The Good And The Bad Of A Potential Alzheimer's Target." ScienceDaily. ScienceDaily, 29 June 2008. <www.sciencedaily.com/releases/2008/06/080627163146.htm>.
American Society for Biochemistry and Molecular Biology. (2008, June 29). The Good And The Bad Of A Potential Alzheimer's Target. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2008/06/080627163146.htm
American Society for Biochemistry and Molecular Biology. "The Good And The Bad Of A Potential Alzheimer's Target." ScienceDaily. www.sciencedaily.com/releases/2008/06/080627163146.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) — Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) — Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) — Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Common Pain Reliever Might Dull Your Emotions

Common Pain Reliever Might Dull Your Emotions

Newsy (Apr. 16, 2015) — Each week, millions of Americans take acetaminophen to dull minor aches and pains. Now researchers say it might blunt life&apos;s highs and lows, too. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins