Featured Research

from universities, journals, and other organizations

Study Examines Testing Model To Predict And Diagnose New Cases Of Dementia

Date:
August 25, 2008
Source:
JAMA and Archives Journals
Summary:
A preliminary report suggests that within-person variability on neuropsychological testing may be associated with development of dementia in older adults.

A preliminary report published in the August 20 issue of JAMA suggests that within-person variability on neuropsychological testing may be associated with development of dementia in older adults.

Related Articles


"Developing strategies to improve the prediction and diagnoses of dementia has paramount therapeutic and public health implications," the authors write. "When neuropsychological tests are used for diagnostic purposes, an individual's level of performance on specific tests is measured against healthy normative samples to determine cognitive impairment. However, this approach does not take into account intra-individual variability in cognitive function." Intra-individual variability is inconsistency in cognitive performance within a person.

Roee Holtzer, Ph.D., and colleagues from the Albert Einstein College of Medicine, Yeshiva University, New York, evaluated 897 individuals, age 70 or older, who are part of The Einstein Aging Study, a longitudinal study of aging and dementia in Bronx County, New York. Participants had follow-up visits every 12 to 18 months, at which they underwent detailed neurological and neuropsychological evaluations. The researchers included tests for verbal IQ, attention/executive function, and memory. The study focused on whether within-person across-neuropsychological test variability predicts future dementia.

"Of the 897 participants, there were 61 cases of incident dementia (6.8 percent) … identified during the follow-up period (mean [average] 3.3 years)," the authors report. "On the basis of the consensus clinical diagnostic procedures, 47 participants developed incident dementia of the Alzheimer type and 18 participants developed incident vascular dementia. During the study, 128 individuals died, as expected for the age of this cohort. Of these, 18 had developed incident dementia."

"In summary, within-person across-neuropsychological test variability was associated with development of dementia independently of performance of the neuropsychological tests. This finding needs to be replicated in different populations before it is applied in a clinical setting," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Roee Holtzer; Joe Verghese; Cuiling Wang; Charles B. Hall; Richard B. Lipton. Within-Person Across-Neuropsychological Test Variability and Incident Dementia. JAMA, 2008; 300 (7): 823-830 [link]

Cite This Page:

JAMA and Archives Journals. "Study Examines Testing Model To Predict And Diagnose New Cases Of Dementia." ScienceDaily. ScienceDaily, 25 August 2008. <www.sciencedaily.com/releases/2008/08/080819170429.htm>.
JAMA and Archives Journals. (2008, August 25). Study Examines Testing Model To Predict And Diagnose New Cases Of Dementia. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2008/08/080819170429.htm
JAMA and Archives Journals. "Study Examines Testing Model To Predict And Diagnose New Cases Of Dementia." ScienceDaily. www.sciencedaily.com/releases/2008/08/080819170429.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
Study Shows Newborn Chicks Count From Left to Right Just Like Humans

Study Shows Newborn Chicks Count From Left to Right Just Like Humans

Buzz60 (Jan. 30, 2015) Researchers for the first time identified human&apos;s innate preference for associating low and high numbers with the left and right respectively in another species. Jen Markham (@jenmarkham) explains. Video provided by Buzz60
Powered by NewsLook.com
Best Mood Elevating, Feel Good Shakes & Smoothies

Best Mood Elevating, Feel Good Shakes & Smoothies

Buzz60 (Jan. 30, 2015) You can elevate your mood by having a meal in a glass. Fitness and nutrition expert John Basedow (@JohnBasedow) offers the best &apos;feel good&apos; smoothies and shakes chock full of depression-relieving ingredients...including apples, berries, lemons, cucumbers, papaya, kiwi, spinach, kale, whey protein, matcha, ginger, turmeric and cinnamon. Video provided by Buzz60
Powered by NewsLook.com
Poll Says Firstborn Is Responsible, Youngest Is Funnier

Poll Says Firstborn Is Responsible, Youngest Is Funnier

Newsy (Jan. 30, 2015) According to a poll out of the U.K., eldest siblings feel more responsible and successful than their younger siblings. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins