Featured Research

from universities, journals, and other organizations

Protein Identified That Plays Role In Blood Flow

Date:
September 22, 2008
Source:
University of Missouri-Columbia
Summary:
Using atomic force microscopy -- a microscope with very high resolution -- and isolating blood vessels outside the body, researchers have identified a protein that plays an important role in the control of tissue blood flow and vascular resistance. This new knowledge brings researchers one step closer to understanding vascular diseases, such as high blood pressure, diabetes and other vascular problems.

For years, researchers have known that high blood pressure causes blood vessels to contract and low blood pressure causes blood vessels to relax. Until recently, however, researchers did not have the tools to determine the exact proteins responsible for this phenomenon.

Related Articles


Now, using atomic force microscopy - a microscope with very high resolution - and isolating blood vessels outside the body, University of Missouri researchers have identified a protein that plays an important role in the control of tissue blood flow and vascular resistance. This new knowledge brings researchers one step closer to understanding vascular diseases, such as high blood pressure, diabetes and other vascular problems.

“This study provides new insights that clarify the role of specific proteins and the vascular smooth muscle cells that control the mechanical activity of blood vessels,” said Gerald Meininger, professor and director of MU’s Dalton Cardiovascular Research Center. “We have identified an important receptor that is responsible for the ability of small arteries in the body. This research provides new clues for the cause of vascular diseases, such as high blood pressure and diabetes and may be used in the future as a possible therapeutic target.”

The researchers isolated blood vessels from the body and used atomic force microscopy to apply a controlled force to particular proteins located on the surface of smooth muscle cells from the blood vessel wall. When force was applied to the proteins, the smooth muscle cells reacted, and constricted or contracted depending on the proteins that were targeted. Testing several proteins, researchers were able to pinpoint which proteins played a role in the mechanics of blood vessels.

In 90 to 95 percent of high blood pressure cases the cause is unknown, according to the American Heart Association. Understanding the role of these proteins in controlling blood vessel function will eventually lead researchers to better answers for treating and preventing vascular disease, Meininger said.


Story Source:

The above story is based on materials provided by University of Missouri-Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sun et al. Extracellular matrix-specific focal adhesions in vascular smooth muscle produce mechanically active adhesion sites. AJP Cell Physiology, 2008; 295 (1): C268 DOI: 10.1152/ajpcell.00516.2007

Cite This Page:

University of Missouri-Columbia. "Protein Identified That Plays Role In Blood Flow." ScienceDaily. ScienceDaily, 22 September 2008. <www.sciencedaily.com/releases/2008/09/080918104227.htm>.
University of Missouri-Columbia. (2008, September 22). Protein Identified That Plays Role In Blood Flow. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/09/080918104227.htm
University of Missouri-Columbia. "Protein Identified That Plays Role In Blood Flow." ScienceDaily. www.sciencedaily.com/releases/2008/09/080918104227.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins