Featured Research

from universities, journals, and other organizations

Memory Improves If Neurons Are New

Date:
October 15, 2008
Source:
CNR-Consiglio Nazionale delle Ricerche
Summary:
The birth of new neurons (neurogenesis) does not end completely during development but continues throughout all life in two areas of the adult nervous system, i.e. subventricular zone and hippocampus. Recent research has shown that hippocampal neurogenesis is crucial for memory formation. These studies, however, have not yet clarified how the newborn neurons are integrated in the existing circuits and thus contribute to new memories formation and to the maintenance of old ones.

The birth of new neurons (neurogenesis) does not end completely during development but continues throughout all life in two areas of the adult nervous system, i.e. subventricular zone and hippocampus. Recent research has shown that hippocampal neurogenesis is crucial for memory formation. These studies, however, have not yet clarified how the newborn neurons are integrated in the existing circuits and thus contribute to new memories formation and to the maintenance of old ones.

The team of researchers of CNR-LUMSA-EBRI at the European Centre for Brain Research, organization established in Rome with the key contribution of the Santa Lucia Foundation, has taken a step forward to understand the requirements of newborn neurons in the process of learning and memory. The neuroscientists coordinated by dr. Felice Tirone of the Institute of Neurobiology and Molecular Medicine (INMM) of CNR, in collaboration with prof. Vincenzo Cestari of the Institute for Neuroscience of CNR and the LUMSA University and with dr. Alberto Bacci of the European Brain Research Institute, have shown that a key factor for neurogenesis is represented by the speed of differentiation of progenitors (stem cells that give rise to neurons) in hippocampus. From such speed will in fact depend the success of the whole process. “New neurons must maturate according to a correct temporal sequence in order to become able to acquire new memories and retrieve the existing ones”, explains Tirone.

This study is based on a new experimental approach, that involves the generation of a mice line in which the differentiation of newborn neurons is accelerated without altering their number. This is obtained by the selective expression in neural progenitors of the hippocampus of PC3/Tis21, a gene specifically able to accelerate the differentiation of these and other types of neural progenitors.

“Compelling new neurons to rush ahead in their differentiation for a predefined time period, we have observed that a small number of neurons of 2-3 weeks of age is critical for learning,” continues the INMM-CNR researcher. “In fact, mice so treated are not only unable to learn new spatial information, but they are also unable to use previously acquired memories.”

“PC3/Tis21, of which we have previously observed an action against brain tumors in consequence of its ability to promote differentiation of neural progenitor cells, might indeed have other practical outcomes” continues Tirone “since it is activated by Nerve Growth Factor, a molecule whose deprivation appears to be an important component of Alzheimer’s disease. In fact hippocampus is one of the first brain regions damaged by Alzheimer’s disease, which is characterized mainly by temporal and spatial disorientation and by a memory deficit. We might gain some useful information also to understand the mechanisms underlying this disease.”

Thus, it is an open and relevant question in neuroscience the understanding of mechanisms and factors that control or influence adult neurogenesis, in the field of memory as these researches now indicate, but also of depression, which, as some researchers have suggested, might take place in consequence of a defective adult neurogenesis.


Story Source:

The above story is based on materials provided by CNR-Consiglio Nazionale delle Ricerche. Note: Materials may be edited for content and length.


Journal Reference:

  1. Farioli-Vecchioli et al. The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory. PLoS Biology, 2008; 6 (10): e246 DOI: 10.1371/journal.pbio.0060246

Cite This Page:

CNR-Consiglio Nazionale delle Ricerche. "Memory Improves If Neurons Are New." ScienceDaily. ScienceDaily, 15 October 2008. <www.sciencedaily.com/releases/2008/10/081007132511.htm>.
CNR-Consiglio Nazionale delle Ricerche. (2008, October 15). Memory Improves If Neurons Are New. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/10/081007132511.htm
CNR-Consiglio Nazionale delle Ricerche. "Memory Improves If Neurons Are New." ScienceDaily. www.sciencedaily.com/releases/2008/10/081007132511.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins