Featured Research

from universities, journals, and other organizations

Alzheimer’s-associated Plaques Found In Symptom-free Older Adults

Date:
November 11, 2008
Source:
University of Pittsburgh Schools of the Health Sciences
Summary:
Pittsburgh Compound B, an imaging agent that could facilitate the early diagnosis of Alzheimer's disease, has been used to identify amyloid deposition in the brains of clinically older adults. The findings could not only shed more light on how the illness progresses, but also open the door to the possibility of prevention strategies.

In the largest study of its kind, Pittsburgh Compound B, an imaging agent that could facilitate the early diagnosis of Alzheimer's disease, has been used to identify amyloid deposition in the brains of clinically older adults.

The findings, published in this month's issue of the Archives of Neurology, could not only shed more light on how the illness progresses, but also open the door to the possibility of prevention strategies, said senior investigator William E. Klunk, M.D., Ph.D., professor of psychiatry and neurology at the University of Pittsburgh School of Medicine.

He and study co-author Chester A. Mathis, Ph.D., a Pitt professor of radiology and pharmaceutical sciences, invented the imaging compound, dubbed PiB. It binds to certain forms of amyloid protein plaques that are thought to destroy brain cells and have been found in the brains of Alzheimer's disease patients. Before PiB, the deposits could only be identified during autopsy to confirm the diagnosis in hindsight.

Results of the study, which was led by Howard J. Aizenstein, M.D., Ph.D., associate professor of psychiatry and bioengineering at Pitt, "show that we can detect amyloid deposits before patients develop symptoms of Alzheimer's disease," Dr. Klunk said. "That means we might have a window of opportunity to slow or stop the process."

One surprising finding was that detailed tests of brain functioning conducted by study co-authors, Robert D. Nebes, Ph.D., professor of psychiatry, and Judith Saxton, Ph.D., associate professor of neurology and psychiatry, both of the University of Pittsburgh, showed no decrease in functioning among participants whose scans revealed the presence of the Alzheimer-associated amyloid deposits.

In the study, 43 people age 65 to 88 who had no impairment on cognitive testing were scanned with PiB and positron emission tomography. Nine of them (21 percent) showed early amyloid deposition in at least one area of the brain, which is similar to rates found in postmortem studies. That suggests there may be as many people in this age group with the early brain changes, but no visible symptoms, of Alzheimer's disease, as there are people with recognized Alzheimer's disease.

"The good news is it appears the brain can tolerate these plaques for years before the effects are apparent," Dr. Klunk noted. "The bad news is that by the time the symptoms emerge, the disease has had perhaps a 10-year head start."

He cautioned, "We suspect that people with amyloid deposits and normal brain functioning have a high risk of developing Alzheimer's disease in the future, but we do not yet have proof of this." Therefore, study protocol prohibits telling the research participants the results of their PiB scans.

"We simply do not yet know what a positive PiB scan means in a normal individual," Dr. Klunk explained. "We believe it is better to not reveal the results than to give a mistaken impression about something so important." The researchers plan to follow these individuals for years in this and larger studies to fully understand how the presence of amyloid deposits translates into future risk for Alzheimer's disease.

The research was supported by grants from the National Institute on Aging, the Alzheimer's Association and the U.S. Department of Energy.


Story Source:

The above story is based on materials provided by University of Pittsburgh Schools of the Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Schools of the Health Sciences. "Alzheimer’s-associated Plaques Found In Symptom-free Older Adults." ScienceDaily. ScienceDaily, 11 November 2008. <www.sciencedaily.com/releases/2008/11/081110163818.htm>.
University of Pittsburgh Schools of the Health Sciences. (2008, November 11). Alzheimer’s-associated Plaques Found In Symptom-free Older Adults. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2008/11/081110163818.htm
University of Pittsburgh Schools of the Health Sciences. "Alzheimer’s-associated Plaques Found In Symptom-free Older Adults." ScienceDaily. www.sciencedaily.com/releases/2008/11/081110163818.htm (accessed September 3, 2014).

Share This



More Mind & Brain News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins