Featured Research

from universities, journals, and other organizations

Lower-dose Fractionated Stereotactic Radiotherapy Results In Better Hearing Preservation

Date:
December 17, 2008
Source:
Thomas Jefferson University
Summary:
Researchers have found that a lower dose of fractionated stereotactic radiotherapy for acoustic neuromas results in better hearing preservation and has the same tumor local control rate as a higher dose of therapy.

Researchers at Thomas Jefferson University have found that a lower dose of fractionated stereotactic radiotherapy for acoustic neuromas results in better hearing preservation and has the same tumor local control rate as a higher dose of therapy.

Related Articles


The study appeared online in the International Journal of Radiation Oncology*Biology*Physics.

"We previously had not determined the optimal dose of fractionated stereotactic radiotherapy for acoustic neuromas," said David W. Andrews, M.D., professor and vice-chairman of the Department of Neurological Surgery at Jefferson Medical College of Thomas Jefferson University, and the lead author. "This study was designed to compare the hearing preservation between the two doses. The lower-dose treatment resulted in a 100 percent tumor control rate, with the advantage of better hearing preservation."

Between 1994 and 2007, 101 patients with serviceable hearing were treated at Jefferson with fractionated stereotactic radiotherapy (FSR). Dr. Andrews and colleagues analyzed 89 patients within that cohort who had complete audiometric data available. Forty-three patients had received the high-dose of 50.4 Gruyere (Gy). Forty-six patients received the low-dose of 46.8 Gy.

The tumor local control rates were 100% for both the lower-dose cohort and the higher-dose cohort. The pure tone average was 33 decibels (dB) in the lower-dose cohort, which was significantly better than the 40 dB pure tone average in the high-dose cohort. The actuarial hearing preservation rate was also longer in the lower-dose cohort: 165 weeks vs. 79 weeks.

"This is a potentially practice-changing finding," Dr. Andrews said. "We are now working to design a study to directly compare FSR with other treatment options, including stereotactic single fraction radiosurgery."

According to Dr. Andrews, the tumor control rates for FSR are comparable to those of stereotactic single fraction radiosurgery, another treatment option for acoustic neuromas. But Dr. Andrews and colleagues found in a previous study that FSR preserves hearing better, and does not cause trigeminal or facial neuropathies.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Lower-dose Fractionated Stereotactic Radiotherapy Results In Better Hearing Preservation." ScienceDaily. ScienceDaily, 17 December 2008. <www.sciencedaily.com/releases/2008/12/081217124422.htm>.
Thomas Jefferson University. (2008, December 17). Lower-dose Fractionated Stereotactic Radiotherapy Results In Better Hearing Preservation. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2008/12/081217124422.htm
Thomas Jefferson University. "Lower-dose Fractionated Stereotactic Radiotherapy Results In Better Hearing Preservation." ScienceDaily. www.sciencedaily.com/releases/2008/12/081217124422.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins