Featured Research

from universities, journals, and other organizations

Diabetes And Elevated Levels Of Cholesterol Linked To Faster Cognitive Decline In Alzheimer's Patients

Date:
March 15, 2009
Source:
Columbia University Medical Center
Summary:
A history of diabetes and elevated levels of cholesterol, especially LDL cholesterol, are associated with faster cognitive decline in patients with Alzheimer's disease, according to a new study. These results add further evidence of the role of vascular risk factors in the onset and progression of Alzheimer's disease.

A history of diabetes and elevated levels of cholesterol, especially LDL cholesterol, are associated with faster cognitive decline in patients with Alzheimer’s disease, according to a new study from Columbia University Medical Center researchers. These results add further evidence of the role of vascular risk factors in the onset and progression of Alzheimer’s disease.

The study will be published in the March 2009 issue of Archives of Neurology. This special issue, titled, Archives of Neurology: Neurological Disorders Related to Obesity, Diabetes Mellitus, the Metabolic Syndrome, and Other Comorbidities, is part of a special JAMA/Archives focus on diabetes and metabolic disorders.

“These findings indicate that controlling vascular conditions may be one way to delay the course of Alzheimer’s, which would be a major development in the treatment of this devastating disease as currently there are few treatments available to slow its progression,” said Yaakov Stern, Ph.D., a professor at the Taub Institute for the Research on Alzheimer’s Disease and the Aging Brain and director of the Cognitive Neuroscience Division of the Gertrude H. Sergievsky Center at Columbia University Medical Center, and senior author of the paper.

“Preventing heart disease, stroke and diabetes – or making sure these conditions are well managed in patients diagnosed with them – can potentially slow the disease progression of Alzheimer’s,” said Dr. Stern.

Dr. Stern and the research team used longitudinal data for a mean of 3.5 years (up to 10.2 years) for 156 people diagnosed with Alzheimer’s disease who were participants in the Washington Heights/Inwood Columbia Aging Project, a 10-year multi-ethnic, prospective, epidemiological study of cognitive aging and dementia in northern Manhattan.

“Through the Washington Heights/Inwood Columbia Aging Project, we were able to follow patients before they began to show symptoms of Alzheimer’s and for several years following their diagnosis. This makes our estimates of progression much more powerful, since we were able to know exactly when cognitive decline began,” said Dr. Stern.

They found that a history of diabetes and higher cholesterol levels (total cholesterol and LDL-C) was associated with faster cognitive decline. A history of heart disease and stroke was found to be associated with cognitive decline only in carriers of the apolipoprotein E ε4 (APOE-ε4) gene, which has been implicated in late-onset Alzheimer’s disease.

Researchers from Columbia’s Taub Institute have previously demonstrated a link between stroke, diabetes, smoking, hypertension and a higher risk of Alzheimer’s disease. While vascular risk factors have been studied as predictors of Alzheimer’s, few studies have assessed their influence on disease progression. As the authors write, “There has been intense interest in identifying modifiable Alzheimer’s disease risk factors such as cardiovascular risk factors, with the goal of preventing or at least delaying disease onset. However, little attention has been given to the influence of these factors on disease progression.”

Dr. Stern and the research team theorize that the link between vascular risk factors and faster cognitive decline in patients with Alzheimer’s disease may occur because vascular diseases may increase oxidative stress or activate inflammation in the brain, thereby triggering the production of amyloid, and/or triggering the formation of neuron tangles – known as neurofibrillary tangles – which are believed to be a primary cause of Alzheimer’s disease.

Dr. Stern and his colleagues are continuing to study the basis of the links between vascular risk factors and Alzheimer's disease using epidemiologic and imaging approaches.


Story Source:

The above story is based on materials provided by Columbia University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Columbia University Medical Center. "Diabetes And Elevated Levels Of Cholesterol Linked To Faster Cognitive Decline In Alzheimer's Patients." ScienceDaily. ScienceDaily, 15 March 2009. <www.sciencedaily.com/releases/2009/03/090309161955.htm>.
Columbia University Medical Center. (2009, March 15). Diabetes And Elevated Levels Of Cholesterol Linked To Faster Cognitive Decline In Alzheimer's Patients. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/03/090309161955.htm
Columbia University Medical Center. "Diabetes And Elevated Levels Of Cholesterol Linked To Faster Cognitive Decline In Alzheimer's Patients." ScienceDaily. www.sciencedaily.com/releases/2009/03/090309161955.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins