Featured Research

from universities, journals, and other organizations

Brain Building: Brain Growth Tied To Cell Division In Mouse Embryos

Date:
April 6, 2009
Source:
Rockefeller University Press
Summary:
How your brain grows might come down to how your cells divide. Scientists report that mouse protein Vangl2 controls the asymmetrical cell division and developmental fate of progenitor neurons.

Early-born neurons (green) are more abundant in the Vangl2-lacking mouse embryo brain (bottom) due to premature progenitor differentiation.
Credit: Lake, B.B., and S.Y. Sokol. 2009. J. Cell Biol. doi:10.1083/jcb.200807073

How your brain grows might come down to how your cells divide. In the April 6 issue of the Journal of Cell Biology (JCB), Lake and Sokol report that mouse protein Vangl2 controls the asymmetrical cell division and developmental fate of progenitor neurons.

Vangl2 (aka Strabismus in flies) is a component of the PCP (planar cell polarity) pathway that is active in a variety of tissues and organisms. Mice that lack Vangl2 have a number of neurological defects including incomplete neural tube closure and reduced brain size.

Sokol and Lake wondered how Vangl2 might influence brain development. In the cerebral cortex, neurons are born from a pool of progenitor cells, and the time of their birth determines their fate. The research duo found that Vangl2-lacking mouse embryos had large numbers of early-born neurons and few remaining progenitor cells. This hinted that Vangl2-lacking neurons were differentiating prematurely—a suspicion confirmed in vitro.

The progenitor pool is maintained by asymmetrical division—one daughter cell becomes a neuron, the other self-renews. This fate asymmetry is thought to depend on the orientation of cell division, and the authors observed an increase in the number of symmetrically dividing progenitors in the brains of Vangl2-lacking mouse embryos. Also, Vangl2-lacking cells in culture showed symmetrical distribution of a spindle-orienting factor that in normal cells distributes asymmetrically.

Such similarities between Vangl2-lacking cells in vitro and in vivo will facilitate ongoing studies of the PCP pathway in neurogenesis.

Journal reference: Lake, B.B., and S.Y. Sokol. 2009. J. Cell Biol. doi:10.1083/jcb.200807073


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "Brain Building: Brain Growth Tied To Cell Division In Mouse Embryos." ScienceDaily. ScienceDaily, 6 April 2009. <www.sciencedaily.com/releases/2009/03/090330091603.htm>.
Rockefeller University Press. (2009, April 6). Brain Building: Brain Growth Tied To Cell Division In Mouse Embryos. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/03/090330091603.htm
Rockefeller University Press. "Brain Building: Brain Growth Tied To Cell Division In Mouse Embryos." ScienceDaily. www.sciencedaily.com/releases/2009/03/090330091603.htm (accessed October 1, 2014).

Share This



More Mind & Brain News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

App Teaches Kindergarteners to Code

App Teaches Kindergarteners to Code

AP (Oct. 1, 2014) They can't all read yet, but soon kindergarteners may be able to create basic computer code. Researchers in Massachusetts developed an app that teaches young kids a simple computer programming language. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
Your Spouse's Personality May Influence Your Earnings

Your Spouse's Personality May Influence Your Earnings

Newsy (Sep. 26, 2014) Research from Washington University suggest people with conscientious spouses have greater career success. Video provided by Newsy
Powered by NewsLook.com
Can A Blood Test Predict Psychosis Risk?

Can A Blood Test Predict Psychosis Risk?

Newsy (Sep. 26, 2014) Researchers say certain markers in the blood can predict risk of psychosis later in the life. The test can aid in early treatment for the condition. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins