Featured Research

from universities, journals, and other organizations

New Tissue Scaffold Regrows Cartilage And Bone

Date:
May 13, 2009
Source:
Massachusetts Institute of Technology
Summary:
Scientists have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints. The scaffold, which recently went into clinical trials, could offer a potential new treatment for sports injuries and other cartilage damage, such as arthritis.

MIT and Cambridge University scientists developed this tissue scaffold that could help repair knees and other joints. The top section, indicated by the green arrow, stimulates bone growth, while the lower half, marked by the orange arrow, stimulates cartilage growth.
Credit: Lorna Gibson

MIT engineers and colleagues have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints.

The scaffold could offer a potential new treatment for sports injuries and other cartilage damage, such as arthritis, says Lorna Gibson, the Matoula S. Salapatas Professor of Materials Science and Engineering and co-leader of the research team with Professor William Bonfield of Cambridge University.

"If someone had a damaged region in the cartilage, you could remove the cartilage and the bone below it and put our scaffold in the hole," said Gibson. The researchers describe their scaffold in a recent series of articles in the Journal of Biomedical Materials Research.

The technology has been licensed to Orthomimetics, a British company launched by one of Gibson's collaborators, Andrew Lynn of Cambridge University. The company recently started clinical trials in Europe.

The scaffold has two layers, one that mimics bone and one that mimics cartilage. When implanted into a joint, the scaffold can stimulate mesenchymal stem cells in the bone marrow to produce new bone and cartilage. The technology is currently limited to small defects, using scaffolds roughly 8 mm in diameter.

The researchers demonstrated the scaffold's effectiveness in a 16-week study involving goats. In that study, the scaffold successfully stimulated bone and cartilage growth after being implanted in the goats' knees.

The project, a collaboration enabled by the Cambridge-MIT Institute, began when the team decided to build a scaffold for bone growth. They started with an existing method to produce a skin scaffold, made of collagen (from bovine tendon) and glycosaminoglycan, a long polysaccharide chain. To mimic the structure of bone, they developed a technique to mineralize the collagen scaffold by adding sources of calcium and phosphate.

Once that was done, the team decided to try to create a two-layer scaffold to regenerate both bone and cartilage (known as an osteochondral scaffold). Their method produces two layers with a gradual transition between the bone and cartilage layers.

"We tried to design it so it's similar to the transition in the body. That's one of the unique things about it," said Gibson.

There are currently a few different ways to treat cartilage injuries, including stimulating the bone marrow to release stem cells by drilling a hole through the cartilage into the bone; transplanting cartilage and the underlying bone from another, less highly loaded part of the joint; or removing cartilage cells from the body, stimulating them to grow in the lab and re-implanting them.

The new scaffold could offer a more effective, less expensive, easier and less painful substitute for those therapies, said Gibson.

MIT collaborators on the project are Professor Ioannis Yannas, of mechanical engineering and biological engineering; Myron Spector of the Harvard-MIT Division of Health Sciences and Technology (HST); Biraja Kanungo, a graduate student in materials science and engineering; recent MIT PhD recipients Brendan Harley (now at the University of Illinois) and Scott Vickers; and Zachary Wissner-Gross, a graduate student in HST. Dr. Hu-Ping Hsu of Harvard Medical School also worked on the project.

Cambridge University researchers involved in the project are Professor William Bonfield, Andrew Lynn, now CEO of Orthomimetics, Dr. Neil Rushton, Serena Best and Ruth Cameron.

The research was funded by the Cambridge-MIT Institute, the Whitaker-MIT Health Science Fund, Universities UK, Cambridge Commonwealth Trust and St. John's College Cambridge.


Story Source:

The above story is based on materials provided by Massachusetts Institute of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts Institute of Technology. "New Tissue Scaffold Regrows Cartilage And Bone." ScienceDaily. ScienceDaily, 13 May 2009. <www.sciencedaily.com/releases/2009/05/090511122429.htm>.
Massachusetts Institute of Technology. (2009, May 13). New Tissue Scaffold Regrows Cartilage And Bone. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2009/05/090511122429.htm
Massachusetts Institute of Technology. "New Tissue Scaffold Regrows Cartilage And Bone." ScienceDaily. www.sciencedaily.com/releases/2009/05/090511122429.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins