Featured Research

from universities, journals, and other organizations

Study May Aid Efforts To Prevent Uncontrolled Cell Division In Cancer

Date:
May 29, 2009
Source:
University of California - San Diego
Summary:
Researchers have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.

Related Articles


The researchers show that – even though both cell volume and the length of the contractile ring are reduced during successive rounds of embryonic cell division – the duration or timing of cell division remains the same. Their study will be published in the May 29 issue of the journal Cell.

"We showed that contractile rings constrict at a constant rate that is proportional to the initial size of the cell, so that rings in larger cells constrict proportionally faster than rings in smaller cells," said Karen Oegema, PhD, associate professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine and the Moores UCSD Cancer Center. "Because of this property, the time required to complete cell division remains the same during embryogenesis, even as cells get smaller."

During their early development, embryos are progressively partitioned into smaller and smaller cells by successive rounds of cell division. The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell. A contractile ring forms a belt around the cell middle; constriction or closure of this ring "tightens the belt," pinching the mother cell into two daughter cells.

In early embryogenesis, cell volume and the length of the contractile ring around the cell middle are reduced at each successive round of cell division. By contrast, the dimension of the chromosomes – which carry the genetic material that is segregated to the daughter cells – remains constant. The discovery that contractile rings constrict at a constant rate, proportionate to the initial cell size, opens the door to further studies of the mechanism.

"Further studies of the contractile ring could ultimately lead to improved therapies for cancer," said first author Ana Carvalho, PhD. "Understanding the cellular machinery required for cell division may teach us how to prevent the uncontrolled cell division that occurs in cancer."

Arshad Desai, PhD, professor at the Ludwig Institute and assistant professor of cellular and molecular medicine at UCSD also contributed to the paper. Funding was provided by the Ludwig Institute for Cancer Research, the Pew Scholars Program in the Biomedical Sciences, the Fundação para a Ciência e Tecnologia, Portugal, and The European Social Fund.


Story Source:

The above story is based on materials provided by University of California - San Diego. The original article was written by Steve Benowitz & Debra Kain. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ana Carvalho, Arshad Desai, Karen Oegema. Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size. Cell, 2009; DOI: 10.1016/j.cell.2009.03.021

Cite This Page:

University of California - San Diego. "Study May Aid Efforts To Prevent Uncontrolled Cell Division In Cancer." ScienceDaily. ScienceDaily, 29 May 2009. <www.sciencedaily.com/releases/2009/05/090528135244.htm>.
University of California - San Diego. (2009, May 29). Study May Aid Efforts To Prevent Uncontrolled Cell Division In Cancer. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/05/090528135244.htm
University of California - San Diego. "Study May Aid Efforts To Prevent Uncontrolled Cell Division In Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/05/090528135244.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins