Featured Research

from universities, journals, and other organizations

Immune Cells Ameliorate Hypertension-induced Cardiac Damage In Mice

Date:
June 12, 2009
Source:
Helmholtz Association of German Research Centres
Summary:
Researchers have found that a specific type of immune cell, the regulatory T lymphocyte plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were infused with angiotensin II, a blood pressure-raising peptide. The Tregs had no influence on the blood pressure response to angiotensin II. Nonetheless, cardiac enlargement, fibrosis, and inflammation was sharply reduced by Treg treatment.

Researchers in Berlin, Germany have found that a specific type of immune cell, the regulatory T lymphocyte (Treg) plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were infused with angiotensin II, a blood pressure-raising peptide. The Tregs had no influence on the blood pressure response to angiotensin II. Nonetheless, cardiac enlargement, fibrosis, and inflammation was sharply reduced by Treg treatment.

Related Articles


Furthermore, the tendency to develop abnormal heart rhythms that could lead to sudden cardiac death was also reduced. Dr. Heda Kvakan and Dr. Dominik N. Müller at the Experimental and Clinical Research Center at the Max Delbrück Center do not intend Treg as a therapy. However, a better understanding of how the immune system fits into hypertension-induced organ damage could result from these studies.*

The researchers transferred Treg cells into mice. These cells normally keep the immune system in balance. If the number of Treg cells is reduced or their function impaired, the immune system gets out of balance and, rather than recognizing and destroying bacteria or viruses, the immune cells attack body tissue or organs instead. Autoimmune diseases, such as diabetes type I or Multiple sclerosis, result from the malfunctioning of the immune system.

Aside from its physiological role in maintaining blood pressure, it has long been known that the hormone angiotensin II plays a pivotal role in the onset of hypertension and in subsequnt hypertensive organ damage, e.g. cardiac hypertrophy.

Angiotensin II also has proinflammatory properties and actives the cells of the immune system. The activation of these cells also seems to have a major part in Angiotension II-induced target organ damage. The researchers wanted to know if the suppression of activated immune cells by Treg cells could reduce cardiac damage.

And indeed, hypertensive mice that had received Treg cells, exhibited less cardiac damage. "Hypertrophy and the thickening of the cardiac walls were reduced, also fibrosis and arrhythmia", Dr. Kvakan explains. The Treg cells had brought the immune cells under their control.

The work of Dr. Kvakan and Dr. Müller is the first study to examine the role of immunosuppressive Treg cells in the pathogenesis of hypertensive target organ damage. They conclude that hypertension-induced cardiac damage is partly due to immunological processes.

No Therapy

The two hypertension researchers make it clear that their experiments with Treg cells in mice are in no case suited for therapy in humans. One reason is that Treg cells are much more difficult to identify in humans than in mice. In addition, it is not known what side effects would occur in human patients following suppression of the immune system with Treg cells .

Nevertheless, Dr. Kvakan and Dr. Müller point out that hypertension can be treated well today.



Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kvakan et al. Regulatory T Cells Ameliorate Angiotensin II-Induced Cardiac Damage. Circulation, 2009; 119 (22): 2904 DOI: 10.1161/CIRCULATIONAHA.108.832782

Cite This Page:

Helmholtz Association of German Research Centres. "Immune Cells Ameliorate Hypertension-induced Cardiac Damage In Mice." ScienceDaily. ScienceDaily, 12 June 2009. <www.sciencedaily.com/releases/2009/06/090609122222.htm>.
Helmholtz Association of German Research Centres. (2009, June 12). Immune Cells Ameliorate Hypertension-induced Cardiac Damage In Mice. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/06/090609122222.htm
Helmholtz Association of German Research Centres. "Immune Cells Ameliorate Hypertension-induced Cardiac Damage In Mice." ScienceDaily. www.sciencedaily.com/releases/2009/06/090609122222.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins