Featured Research

from universities, journals, and other organizations

Characteristic Pathological Findings In Reflux Esophagitis

Date:
August 10, 2009
Source:
World Journal of Gastroenterology
Summary:
Although gastroesophageal reflux disease-related extraesophageal syndromes have attracted attention, how gastric-juice reflux influences the esophagus and/or extraesophageal structures is unknown. A research team form Japan explored the pathological findings in the entire esophagus and the effects of ecabet sodium. The results showed that mucosal inflammation extended to the upper esophagus close to the hypopharynx and ES may have a protective role in reflux esophagitis.

Recently, the number of patients with GERD has increased in Japan. However, there have been few reports about the pathological findings in the esophageal squamous epithelium, and there are differing opinions among pathologists about the findings considered characteristic of chronic reflux esophagitis.

Dr. Daisuke Asaoka and his colleagues from Juntendo University (Japan) used a rat model of chronic acid-reflux esophagitis to explore the esophageal mucosal damage macroscopically and microscopically throughout the entire esophagus, including the upper esophagus close to the hypopharynx, and to investigate the protective effects of ecabet sodium (ES) on the esophageal mucosa. This will be published on July 28, 2009 in the World Journal of Gastroenterology,

Their research revealed that epithelial thickening occurs at the same time as inflammatory cell infiltration in the middle to lower esophagus in chronic acid-reflux esophagitis. Furthermore, they demonstrated that inflammatory cells infiltrated the epithelium of the upper esophagus close to the hypopharynx, where there was no evidence of ulcers. These findings suggested that the reflux of gastric juice can extend to the upper esophagus close to the hypopharynx.

Moreove, the research also demonstrated that ES inhibited the epithelial thickening of the lower and middle esophagus, which suggested that ES may play a useful defensive role in the prevention of reflux esophagitis.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Asaoka et al. Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis. World Journal of Gastroenterology, 2009; 15 (28): 3480 DOI: 10.3748/wjg.15.3480

Cite This Page:

World Journal of Gastroenterology. "Characteristic Pathological Findings In Reflux Esophagitis." ScienceDaily. ScienceDaily, 10 August 2009. <www.sciencedaily.com/releases/2009/08/090810104757.htm>.
World Journal of Gastroenterology. (2009, August 10). Characteristic Pathological Findings In Reflux Esophagitis. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2009/08/090810104757.htm
World Journal of Gastroenterology. "Characteristic Pathological Findings In Reflux Esophagitis." ScienceDaily. www.sciencedaily.com/releases/2009/08/090810104757.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins