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Characteristic Pathological Findings In Reflux Esophagitis

Date:
August 10, 2009
Source:
World Journal of Gastroenterology
Summary:
Although gastroesophageal reflux disease-related extraesophageal syndromes have attracted attention, how gastric-juice reflux influences the esophagus and/or extraesophageal structures is unknown. A research team form Japan explored the pathological findings in the entire esophagus and the effects of ecabet sodium. The results showed that mucosal inflammation extended to the upper esophagus close to the hypopharynx and ES may have a protective role in reflux esophagitis.

Recently, the number of patients with GERD has increased in Japan. However, there have been few reports about the pathological findings in the esophageal squamous epithelium, and there are differing opinions among pathologists about the findings considered characteristic of chronic reflux esophagitis.

Dr. Daisuke Asaoka and his colleagues from Juntendo University (Japan) used a rat model of chronic acid-reflux esophagitis to explore the esophageal mucosal damage macroscopically and microscopically throughout the entire esophagus, including the upper esophagus close to the hypopharynx, and to investigate the protective effects of ecabet sodium (ES) on the esophageal mucosa. This will be published on July 28, 2009 in the World Journal of Gastroenterology,

Their research revealed that epithelial thickening occurs at the same time as inflammatory cell infiltration in the middle to lower esophagus in chronic acid-reflux esophagitis. Furthermore, they demonstrated that inflammatory cells infiltrated the epithelium of the upper esophagus close to the hypopharynx, where there was no evidence of ulcers. These findings suggested that the reflux of gastric juice can extend to the upper esophagus close to the hypopharynx.

Moreove, the research also demonstrated that ES inhibited the epithelial thickening of the lower and middle esophagus, which suggested that ES may play a useful defensive role in the prevention of reflux esophagitis.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Asaoka et al. Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis. World Journal of Gastroenterology, 2009; 15 (28): 3480 DOI: 10.3748/wjg.15.3480

Cite This Page:

World Journal of Gastroenterology. "Characteristic Pathological Findings In Reflux Esophagitis." ScienceDaily. ScienceDaily, 10 August 2009. <www.sciencedaily.com/releases/2009/08/090810104757.htm>.
World Journal of Gastroenterology. (2009, August 10). Characteristic Pathological Findings In Reflux Esophagitis. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/08/090810104757.htm
World Journal of Gastroenterology. "Characteristic Pathological Findings In Reflux Esophagitis." ScienceDaily. www.sciencedaily.com/releases/2009/08/090810104757.htm (accessed October 1, 2014).

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