Featured Research

from universities, journals, and other organizations

Nanoparticle-based Battlefield Pain Treatment Moves A Step Closer

Date:
September 25, 2009
Source:
University of Michigan Health System
Summary:
Nanotechnology scientists have developed a combination drug that promises a safer, more precise way for medics and fellow soldiers in battle to give a fallen soldier both morphine and a drug that limits morphine's dangerous side effects. The scientists will devise ultra-small polymer particles capable of carrying the drugs into the body.

University of Michigan scientists have developed a combination drug that promises a safer, more precise way for medics and fellow soldiers in battle situations to give a fallen soldier both morphine and a drug that limits morphine’s dangerous side effects.

Related Articles


They use nanotechnology to devise ultra-small polymer particles capable of carrying the drugs into the body. The development of the combination drug makes possible a precise feedback system that can safely regulate release of the drugs aboard the nanoparticles.

The scientists at the Michigan Nanotechnology Institute for Medicine and Biological Sciences report their results in the September issue of Bioorganic & Medicinal Chemistry Letters.

Context

Soldiers injured in combat typically receive morphine as soon as possible to relieve pain. Morphine, however, also depresses normal breathing and blood pressure, sometimes to life-threatening levels. So medics need to give a short-acting drug that aids normal respiration and heart beat, but in doses that still allow the morphine to relieve pain effectively. Today, achieving that balance is a challenge outside a hospital.

The combination drug that U-M scientists have developed promises to make balanced treatment possible even in combat zones, says James R. Baker, Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS) and the study’s senior author.

“This system could improve pain management for millions of patients with chronic illnesses,” says Baker, Ruth Dow Doan Professor and allergy division chief in the U-M Department of Internal Medicine.

The long-range goal of the research, funded by the U.S. Defense Advanced Research Projects Agency, is to develop a practical method that medics or soldiers themselves could administer, perhaps using an auto-injector device.

Research details

U-M chemists screened several compounds to search for a successful “pro drug,” a drug that can release or become another drug. In this case, they wanted one that could convert to Naloxone, a drug now used to counter morphine’s effects, but would activate only when blood oxygen levels drop too low.

In laboratory tests using human plasma, one pro drug successfully sensed oxygen levels and turned on or off as needed.

“When respiratory distress is too severe, that will trigger release of Naloxone, the antagonist (morphine-suppressing) drug. When the oxygen blood levels go up, that will stop the action of the antagonist drug and more morphine will be available,” says Baohua Huang, Ph.D., the study’s first author and a research investigator at the Michigan Nanotechnology Institute and in Internal Medicine.

What’s next

MNIMBS scientists are proceeding with animal studies of the pro drug’s effects and will develop a dendrimer that can carry the pro drug and morphine, using a dendrimer platform technology previously developed at U-M. They hope to advance to more animal and eventually human studies.

Patents/Disclosures: Patent applications have been filed on related U-M dendrimer inventions.

Additional U-M authors: Shengzhuang Tang, M.S., MNIMBS; Ankur Desai, M.S., MNMBS; Xue-min Cheng, Ph.D., adjunct research associate professor, Department of Internal Medicine and MNIMBS; Alina Kotlyar, M.S., MNIMBS; Abraham Van Der Spek, M.D., associate professor of anesthesiology, and Thommey P. Thomas, Ph.D., research assistant professor, Department of Internal Medicine and MNIMBS.

Funding: Defense Advanced Research Projects Agency, part of the U.S. Department of Defense.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Baohua Huang, Shengzhuang Tang, Ankur Desai, Xue-min Cheng, Alina Kotlyar, Abraham Van Der Spek, Thommey P. Thomas, James R. Baker Jr. Human plasma-mediated hypoxic activation of indolequinone-based naloxone pro-drugs. Bioorganic & Medicinal Chemistry Letters, 2009; 19 (17): 5016 DOI: 10.1016/j.bmcl.2009.07.061

Cite This Page:

University of Michigan Health System. "Nanoparticle-based Battlefield Pain Treatment Moves A Step Closer." ScienceDaily. ScienceDaily, 25 September 2009. <www.sciencedaily.com/releases/2009/09/090924141800.htm>.
University of Michigan Health System. (2009, September 25). Nanoparticle-based Battlefield Pain Treatment Moves A Step Closer. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2009/09/090924141800.htm
University of Michigan Health System. "Nanoparticle-based Battlefield Pain Treatment Moves A Step Closer." ScienceDaily. www.sciencedaily.com/releases/2009/09/090924141800.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins