Featured Research

from universities, journals, and other organizations

New treatment more than doubles survival for high risk childhood leukemia

November 28, 2009
Child & Family Research Institute
Phase 2 study results show high-dose imatinib plus chemo more than doubled survival for high risk type of childhood leukemia.

Results of a phase two clinical trial published October 5th in the Journal of Clinical Oncology show that adding continuous daily doses of a targeted drug called imatinib mesylate to regular chemotherapy more than doubled three-year survival rates for children with a high risk type of blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

The Children's Oncology Group performed the study at nearly 20 North American centres under the leadership of Dr. Kirk Schultz, head of childhood cancer research at the Child & Family Research Institute (CFRI) and a pediatric oncologist at BC Children's Hospital, an agency of the Provincial Health Services Authority.

"With conventional chemotherapy, the three-year survival rate for children with this high-risk type of leukemia is between 30-35 per cent," says Dr. Kirk Schultz, professor of pediatrics at the University of British Columbia.

"Adding continuous exposure to imatinib for two-and-a-half years made a big difference and increased the survival rates to 87 per cent. The drug was well tolerated and it didn't have any significant side effects," he says. Survival rate refers to the length of time that a patient survived without a relapse and without developing a new cancer.

There are multiple types of acute lymphoblastic leukemia and each responds differently to treatment. Ph+ ALL involves genetic abnormalities on two specific chromosomes.

Because traditional chemotherapy doesn't work well for many children with Ph+ ALL, the standard treatment is blood and marrow transplantation, a life-saving procedure that's associated with a risk of complications.

"By using the targeted drug imatinib in combination with traditional chemotherapy, these results suggest that we've been able to improve survival enough that we may no longer have to do blood and marrow transplants for this disease," says Dr. Schultz. "Understanding more about the genetics of cancers allows us to determine the best way to treat each child and be more selective in the appropriate use of expensive medications."

Known commercially as Gleevecฎ, imatinib is a pill that's used to treat some adult leukemias and gastrointestinal cancers. It binds to a specific protein in cancer cells and prevents the cells from proliferating.

Collaborative networks such as the Children's Oncology Group are crucial for recruiting sufficient numbers of patients to trial new treatments for rare diseases such as Ph+ ALL, which is diagnosed in approximately six children and 90 adults each year in Canada.

For this study, there were 92 children and adolescents between one and 21 years of age with Ph+ ALL. Each received an initial four weeks of standard chemotherapy. They were assigned to five different groups that received imatinib for different lengths of time: either 42, 63, 84, 126, or 280 days. All patients received an additional 336 days of imatinib.

The group that received imatinib for more than 280 continuous days had survival rates of 87 per cent, a dramatic improvement over traditional chemotherapy and blood and marrow transplantation. Groups that received imatinib for 84 and 126 days showed moderate improvement in survival rates, while groups receiving the drug for 42 and 63 days had the same survival rates as current standard treatments. There were also 21 patients with Ph+ ALL who were treated with blood and marrow transplantation followed by six months of imatinib. This approach didn't affect survival rates.

"Using imatinib plus chemotherapy had a synergistic type of interaction," says Dr. Schultz. "I never expected these results. Although it's very promising, we need to do more follow up to get the five-year survival data and determine the long-term survival. We submitted our study for publication earlier instead of waiting because the data was so exciting and this type of leukemia is such high risk."

The researchers are now looking at setting up a phase three study to validate whether adding imatinib to chemotherapy could replace blood and marrow transplantation as the standard treatment for Ph+ ALL.

"Using other targeted drugs with regular chemotherapy might give results for other types of cancer in children and adults," says Dr. Schultz.

The study was funded by the National Cancer Institute of the U.S. National Institutes of Health. During the course of the study, Dr. Schultz held the Wyeth/ Canadian Institutes of Health Research Clinical Research Chair in Transplantation.

Story Source:

The above story is based on materials provided by Child & Family Research Institute. Note: Materials may be edited for content and length.

Cite This Page:

Child & Family Research Institute. "New treatment more than doubles survival for high risk childhood leukemia." ScienceDaily. ScienceDaily, 28 November 2009. <www.sciencedaily.com/releases/2009/10/091006173548.htm>.
Child & Family Research Institute. (2009, November 28). New treatment more than doubles survival for high risk childhood leukemia. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/10/091006173548.htm
Child & Family Research Institute. "New treatment more than doubles survival for high risk childhood leukemia." ScienceDaily. www.sciencedaily.com/releases/2009/10/091006173548.htm (accessed September 22, 2014).

Share This

More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations

Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.


Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News


Free Subscriptions

Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins