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Etiological role for H. pylori in autoimmune gastritis

Date:
January 20, 2010
Source:
World Journal of Gastroenterology
Summary:
Autoimmune type atrophic gastritis is a severe gastric atrophy associated with vitamin B12 deficiency. The reason for the disappearance of acid secreting cells from gastric mucosa is not fully understood, but the role of Helicobacter pylori in initiating the mucosal damage is suspected in animal studies. A study found signs of previous H. pylori infection in patients with autoimmune type atrophic gastritis.
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Autoimmune type atrophic gastritis is a severe gastric atrophy associated with vitamin B12 deficiency. The reason for the disappearance of acid secreting cells from gastric mucosa is not fully understood, but the role of Helicobacter pylori in initiating the mucosal damage is suspected in animal studies. A study found signs of previous H. pylori infection in patients with autoimmune type atrophic gastritis.

Experimental animal studies have shown that H. pylori shares several antigenic regions in common with acid secreting cells in gastric mucosa. Antibodies triggered by H. pylori destroy acid secreting cells due this antigenic mimicry. H. pylori infection is very common in humans, and about half of the infected patients develop atrophic changes over the years. In end stage severe atrophy, H. pylori disappears and signs of a previous infection are difficult to detect.

This research, lead by Dr. L Veijola and her colleagues in the University of Helsinki, Finland, has recently been published on January 7 , 2010 in World Journal of Gastroenterology. This study also confirmed the findings of previous studies that the serum markers of autoimmune gastritis appear with increasing frequency in patients with H. pylori infection, when the acid secreting capacity vanishes. The prevention of autoimmune atrophic gastritis, and thus pernicious anaemia, by eradicating the H. pylori would make the lifelong vitamin B12 substitution therapy unnecessary.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Veijola LI, Oksanen AM, Sipponen PI, Rautelin HIK. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection. World J Gastroenterol, 2010; 16(1): 83-88 [link]

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World Journal of Gastroenterology. "Etiological role for H. pylori in autoimmune gastritis." ScienceDaily. ScienceDaily, 20 January 2010. <www.sciencedaily.com/releases/2010/01/100114091212.htm>.
World Journal of Gastroenterology. (2010, January 20). Etiological role for H. pylori in autoimmune gastritis. ScienceDaily. Retrieved May 28, 2015 from www.sciencedaily.com/releases/2010/01/100114091212.htm
World Journal of Gastroenterology. "Etiological role for H. pylori in autoimmune gastritis." ScienceDaily. www.sciencedaily.com/releases/2010/01/100114091212.htm (accessed May 28, 2015).

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