Featured Research

from universities, journals, and other organizations

Etiological role for H. pylori in autoimmune gastritis

Date:
January 20, 2010
Source:
World Journal of Gastroenterology
Summary:
Autoimmune type atrophic gastritis is a severe gastric atrophy associated with vitamin B12 deficiency. The reason for the disappearance of acid secreting cells from gastric mucosa is not fully understood, but the role of Helicobacter pylori in initiating the mucosal damage is suspected in animal studies. A study found signs of previous H. pylori infection in patients with autoimmune type atrophic gastritis.

Autoimmune type atrophic gastritis is a severe gastric atrophy associated with vitamin B12 deficiency. The reason for the disappearance of acid secreting cells from gastric mucosa is not fully understood, but the role of Helicobacter pylori in initiating the mucosal damage is suspected in animal studies. A study found signs of previous H. pylori infection in patients with autoimmune type atrophic gastritis.

Experimental animal studies have shown that H. pylori shares several antigenic regions in common with acid secreting cells in gastric mucosa. Antibodies triggered by H. pylori destroy acid secreting cells due this antigenic mimicry. H. pylori infection is very common in humans, and about half of the infected patients develop atrophic changes over the years. In end stage severe atrophy, H. pylori disappears and signs of a previous infection are difficult to detect.

This research, lead by Dr. L Veijola and her colleagues in the University of Helsinki, Finland, has recently been published on January 7 , 2010 in World Journal of Gastroenterology. This study also confirmed the findings of previous studies that the serum markers of autoimmune gastritis appear with increasing frequency in patients with H. pylori infection, when the acid secreting capacity vanishes. The prevention of autoimmune atrophic gastritis, and thus pernicious anaemia, by eradicating the H. pylori would make the lifelong vitamin B12 substitution therapy unnecessary.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Veijola LI, Oksanen AM, Sipponen PI, Rautelin HIK. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection. World J Gastroenterol, 2010; 16(1): 83-88 [link]

Cite This Page:

World Journal of Gastroenterology. "Etiological role for H. pylori in autoimmune gastritis." ScienceDaily. ScienceDaily, 20 January 2010. <www.sciencedaily.com/releases/2010/01/100114091212.htm>.
World Journal of Gastroenterology. (2010, January 20). Etiological role for H. pylori in autoimmune gastritis. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/01/100114091212.htm
World Journal of Gastroenterology. "Etiological role for H. pylori in autoimmune gastritis." ScienceDaily. www.sciencedaily.com/releases/2010/01/100114091212.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins