Featured Research

from universities, journals, and other organizations

'Jekyll and Hyde' cell may hold key to muscular dystrophy, fibrosis treatment

Date:
January 20, 2010
Source:
University of British Columbia
Summary:
Researchers have identified fat-producing cells that possess "dual-personalities" and may further the development of treatments for muscle diseases such as muscular dystrophy and fibrosis.

A team of University of British Columbia researchers has identified fat-producing cells that possess "dual-personalities" and may further the development of treatments for muscle diseases such as muscular dystrophy and fibrosis.

The team found a new type of fibro/adipogenic progenitors, or FAPs, that generate fatty fibrous tissues when transplanted into damaged muscles in mice. Progenitors are similar to stem cells in their capacity to differentiate, but are limited in the number of times they can divide.

The findings are published in the current issue of Nature Cell Biology.

"These cells are typically dormant in muscle tissues," says lead author Fabio Rossi, Canada Research Chair in Regenerative Medicine. "Once activated by damage, they produce signals that coordinate tissue regeneration and then disappear. That's the Dr. Jekyll side of FAPs.

"In chronic muscle diseases such as muscular dystrophy, however, FAPs persist and may be contributing to over-production of scar tissues, resulting in fibrosis. That's the Mr. Hyde side," says Rossi, associate professor in the Department of Medical Genetics and the Biomedical Research Centre.

Better understanding of the role of FAPs could help encourage their healthy function or repress their negative impact, the researchers say. In the long term, drugs targeting these cells may be useful in a range of diseases characterized by fibrosis ranging from cardiovascular to lung and kidney disease, to organ transplantation. In addition, the cells' ability to generate new fat tissue could be exploited to target metabolic disease.

The study was supported by funding from the Canadian Institutes of Health Research, the Michael Smith Foundation for Health Research and The Foundation for Cell Therapy. The Biomedical Research Centre is affiliated with the Vancouver Coastal Health Research Institute.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University of British Columbia. "'Jekyll and Hyde' cell may hold key to muscular dystrophy, fibrosis treatment." ScienceDaily. ScienceDaily, 20 January 2010. <www.sciencedaily.com/releases/2010/01/100118091051.htm>.
University of British Columbia. (2010, January 20). 'Jekyll and Hyde' cell may hold key to muscular dystrophy, fibrosis treatment. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/01/100118091051.htm
University of British Columbia. "'Jekyll and Hyde' cell may hold key to muscular dystrophy, fibrosis treatment." ScienceDaily. www.sciencedaily.com/releases/2010/01/100118091051.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins