Featured Research

from universities, journals, and other organizations

New genetic risk factors for brain aneurysms identified

Date:
April 5, 2010
Source:
Yale University
Summary:
In the largest genome-wide study of brain aneurysms ever conducted, an international team of researchers has identified three new genetic variants that increase a person's risk for developing this deadly disease.

In the largest genome-wide study of brain aneurysms ever conducted, an international team led by researchers at the Yale School of Medicine has identified three new genetic variants that increase a person's risk for developing this deadly disease.

Related Articles


The massive study of intracranial aneurysms involved more than 20,000 subjects and was published in the April 4 online edition of the journal Nature Genetics. The new study, the second by Yale researchers published within the last 15 months, brings to five the number of regions of the genome that have been found to contribute to the nearly 500,000 cases of this devastating disorder diagnosed worldwide annually.

"These findings provide important new insights into the causes of intracranial aneurysms and are a critical step forward in the development of a diagnostic test that can identify people at high risk prior to the emergence of symptoms," said Murat Gunel, professor of neurosurgery, genetics and neurobiology at Yale and senior author of the paper. "Given the often-devastating consequences of the bleeding in the brain, early detection can be the difference between life and death."

The ambitious international collaboration was headed by Gunel and Richard Lifton, Sterling Professor and chair of the Department of Genetics at Yale and a Howard Hughes Medical Institute Investigator. Sixty-nine authors from 32 institutions in 10 countries contributed to the findings by analyzing 5,891 aneurysm patients from Japan and Europe and 14,181 unaffected subjects. They searched across the entire genome for changes in the genetic code that were shared more often by aneurysm patients than by unaffected individuals. The researchers determined that if a person carries all of the risk variants discovered by the Yale-led team, they are five to seven times more likely to suffer an aneurysm than those individuals who carry none.

Gunel and Lifton noted that such huge studies are possible only because of the dramatic improvement in speed and efficiency of genomics technology and the cooperation from nearly 70 international researchers who recruited thousands of subjects and collected DNA samples.

While these findings have transformed the understanding of the genetic risks for intracranial aneurysms, considerable work remains, note the researchers. "These five findings explain about 10 percent of genetic risk of suffering an aneurysm," Gunel said. "This is 10 percent more than we understood just a couple of years ago, but there is a long way to go."

Lifton agrees: "While much remains to be done, this study provides fundamental new clues about the causes of this catastrophic disease that point to new opportunities for early diagnosis and therapeutic intervention."

The median age when aneurismal hemorrhagic stroke occurs is 50 years old, and there are typically no warning signs. In the majority of cases, the resulting strokes cause death or severe brain damage. Without a way to diagnose aneurysms prior to these events, physicians have been mostly left to respond after the fact, once the damage has largely been done, Gunel said.

"Although we face many more challenges, we now achieved the first steps necessary to attain over a decade long goal of early diagnosis and biology-based treatments of aneurysms," he said.

Other Yale authors were Katsuhito Yasuno, Kaya Bilguvar, Nikhil Nayak (YMS), Ali K Ozturk, Emilia Gaal, Matthew State and Shrikant Mane. The study was funded by Yale Center for Human Genetics and Genomics and the Yale Program on Neurogenetics, a Clinical & Translational Science Award, the National Institutes of Health, the Howard Hughes Medical Institute along with a grant from European Commission, VIth Framework Programme.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yasuno et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 2010; DOI: 10.1038/ng.563

Cite This Page:

Yale University. "New genetic risk factors for brain aneurysms identified." ScienceDaily. ScienceDaily, 5 April 2010. <www.sciencedaily.com/releases/2010/04/100404203126.htm>.
Yale University. (2010, April 5). New genetic risk factors for brain aneurysms identified. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2010/04/100404203126.htm
Yale University. "New genetic risk factors for brain aneurysms identified." ScienceDaily. www.sciencedaily.com/releases/2010/04/100404203126.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins