Featured Research

from universities, journals, and other organizations

Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer, study finds

Date:
April 5, 2010
Source:
University of Gothenburg
Summary:
Previous research has shown that women with breast cancer are more likely than other women to develop ovarian cancer, but now researchers have shown that actually only women with a known Western Swedish mutation behind hereditary breast cancer run this increased risk of ovarian cancer.

Previous research has shown that women with breast cancer are more likely than other women to develop ovarian cancer, but now researchers from the Sahlgrenska Academy at the University of Gothenburg, Sweden, have shown that actually only women with a known Western Swedish mutation behind hereditary breast cancer run this increased risk of ovarian cancer.

The study, published in the journal Acta Oncologica, shows that the increased risk of ovarian cancer is linked to a known mutation in women with breast cancer in Western Sweden. The research team had previously identified a special mutation in the breast cancer gene BRCA1 originating with some distant forefather on Sweden's West Coast many generations back. The mutation is often seen in families where three or more members develop breast and/or ovarian cancer and where someone under 50 is diagnosed with breast and/or ovarian cancer.

"Our previous research showed that Western Swedish women with breast cancer are more likely to develop ovarian cancer than women diagnosed with breast cancer in other parts of the country," says Per Karlsson, associate professor from the Department of Oncology and leader of the research team at the Cancer Genetics Clinic at Sahlgrenska University Hospital.

Most ovarian tumours are benign, especially in younger women, but more than 700 women in Sweden are diagnosed with ovarian cancer each year, some 30-40 of them as a result of the Western Swedish BRCA1 mutation. Now the researchers have shown that the increased risk of ovarian cancer among women diagnosed with breast cancer is due solely to this known mutation in the breast cancer gene BRCA1. Their research results reveal that women diagnosed with breast cancer who do not have this mutation do not run an increased risk of ovarian cancer.

"This means that we can focus our investigations and screening on families where many relatives have had breast and ovarian cancer," says Karlsson.

As this elevated risk of ovarian cancer affects only a very small proportion of women with breast cancer, the next step is to provide patients with clearer information about the risks associated with breast cancer when visiting the doctor.

"There is also research under way in the cancer genetics field which may mean that, in future, patients can receive more specific screening, and that cancer patients can expect a more personalised treatment," says Karlsson, who believes that this work could lead to fewer screenings and fewer side-effects from cancer treatments.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zakaria Einbeigi, Charlotta Enerbδck, Arne Wallgren, Margareta Nordling, Per Karlsson. BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer -- a population based study from the Western Sweden Health Care region. Acta Oncologica, 2010; 100215035239084 DOI: 10.3109/02841860903521095

Cite This Page:

University of Gothenburg. "Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer, study finds." ScienceDaily. ScienceDaily, 5 April 2010. <www.sciencedaily.com/releases/2010/04/100404203209.htm>.
University of Gothenburg. (2010, April 5). Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer, study finds. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/04/100404203209.htm
University of Gothenburg. "Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/04/100404203209.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) — The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) — A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) — A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) — A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins